Selenium levels in colorectal cancer: A systematic review and meta-analysis of serum, plasma, and colorectal specimens

A. Pal, A. Dhar, M. A. Shamim, I. Rani, R. R. Negi, A. Sharma, N. Chatterjee, A. Goyal, Sadashiv, B. Kaur, Vincenzo Tondolo, M. Rongioletti, S. R. Samantaray, M. Hoque, A. Pawar, K. Goswami, R. Squitti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Colorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially protective effect of selenium (Se), but the reports are inconsistent. The objective of the study was to examine the evidence for relation between serum/tissue Se status and CRC. Method and materials: In this Systematic Review and Meta-Analysis, we searched Cochrane Library, EBSCOhost, EMBASE, ProQuest, PubMed/MEDLINE, Scopus, and Web of Science for studies reporting serum/plasma/whole blood/tissue Se concentrations in CRC patients and controls for articles published till August 2023. Meta-analysis was performed, and study quality, heterogeneity, and small study effects were assessed. Based on a random effects model, summary mean differences in serum levels of Se between CRC patients and healthy controls, and Se levels between malignant and matched non-malignant tissue specimens were assessed. Results: After initial screening, a total of 24 studies (18 serum and 6 tissue studies) with a pooled total of 2640 participants were included in the meta-analysis. CRC patients had significantly lower serum Se levels than healthy controls, being the difference between the two equal to 3.73 µg/dl (95% CI: 6.85–0.61). However, the heterogeneity was very high, I2= 99% (p < 0.01). Our meta-analysis showed higher Se levels in CRC cancerous specimens than in matched healthy colon tissue: the increase was equal to 0.07 µg/g wet tissue weight (95% CI: 0.06–0.09; p= 0.02). Conclusions: CRC patients have lower serum and higher colon cancerous tissue Se levels. Some factors, such as Se levels in different tumor grades of CRC need to be further considered for a more conclusive association between Se levels and risk of CRC.
Lingua originaleEnglish
pagine (da-a)-
RivistaJournal of Trace Elements in Medicine and Biology
Volume84
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • Colorectal cancer
  • Systematic Reviews and Meta-analysis
  • Selenium

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