Selenium Concentrations and Mortality Among Community-Dwelling Older Adults: Results from ilSIRENTE Study

Silvia Giovannini*, Graziano Onder, F. Lattanzio, S. Bustacchini, G. Di Stefano, R. Moresi, Andrea Russo, Roberto Bernabei, Francesco Landi

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. Objectives: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Design and Setting: Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants and measurements: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. Results: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Conclusions: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
Lingua originaleEnglish
pagine (da-a)608-612
Numero di pagine5
Stato di pubblicazionePubblicato - 2018


  • Aged
  • Aged, 80 and over
  • Female
  • Frail Elderly
  • Humans
  • Independent Living
  • Inflammation
  • Italy
  • Longevity
  • Male
  • Mortality
  • Prospective Studies
  • Selenium
  • frail elderly
  • mortality


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