Abstract
Background: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. Objectives: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Design and Setting: Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants and measurements: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. Results: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Conclusions: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
Lingua originale | English |
---|---|
pagine (da-a) | 608-612 |
Numero di pagine | 5 |
Rivista | THE JOURNAL OF NUTRITION, HEALTH & AGING |
Volume | 22 |
DOI | |
Stato di pubblicazione | Pubblicato - 2018 |
Keywords
- Aged
- Aged, 80 and over
- Female
- Frail Elderly
- Humans
- Independent Living
- Inflammation
- Italy
- Longevity
- Male
- Mortality
- Prospective Studies
- Selenium
- frail elderly
- mortality