Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Vincenzo Valentini; Ruud G.P.M. Van Stiphout; Guido Lammering; Maria Antonietta Gambacorta; Maria C. Barba; Marek Bebenek; Franck Bonnetain; Jean F. Bosset; Krzysztof Bujko; Luca Cionini; Jean P. Gerard; Claus Rödel; Aldo Sainato; Rolf Sauer; Bruce D. Minsky; Laurence Collette; Philippe Lambin

doi:10.1016/j.radonc.2015.02.001

Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Vincenzo Valentini
, Ruud G.P.M. Van Stiphout
, Guido Lammering
, Maria Antonietta Gambacorta
, Maria C. Barba
, Marek Bebenek
, Franck Bonnetain
, Jean F. Bosset
, Krzysztof Bujko
, Luca Cionini
, Jean P. Gerard
, Claus Rödel
, Aldo Sainato
, Rolf Sauer
, Bruce D. Minsky
, Laurence Collette
, Philippe Lambin

Risultato della ricerca: Contributo in rivista › Articolo

30 Citazioni (Scopus)

Abstract

Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.

Lingua originale	Inglese
pagine (da-a)	302-309
Numero di pagine	8
Rivista	Radiotherapy and Oncology
Volume	114
DOI	https://doi.org/10.1016/j.radonc.2015.02.001
Stato di pubblicazione	Pubblicato - 2015

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Keywords

Disease-free survival
Pathological complete response
Personalized treatment
Prediction models
Rectal cancer
Risk ratio

Accesso al documento

10.1016/j.radonc.2015.02.001

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Valentini, V., Van Stiphout, R. G. P. M., Lammering, G., Gambacorta, M. A., Barba, M. C., Bebenek, M., Bonnetain, F., Bosset, J. F., Bujko, K., Cionini, L., Gerard, J. P., Rödel, C., Sainato, A., Sauer, R., Minsky, B. D., Collette, L., & Lambin, P. (2015). Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer. Radiotherapy and Oncology, 114, 302-309. https://doi.org/10.1016/j.radonc.2015.02.001

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title = "Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer",

abstract = "Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.",

keywords = "Disease-free survival, Pathological complete response, Personalized treatment, Prediction models, Rectal cancer, Risk ratio, Disease-free survival, Pathological complete response, Personalized treatment, Prediction models, Rectal cancer, Risk ratio",

author = "Vincenzo Valentini and \{Van Stiphout\}, \{Ruud G.P.M.\} and Guido Lammering and Gambacorta, \{Maria Antonietta\} and Barba, \{Maria C.\} and Marek Bebenek and Franck Bonnetain and Bosset, \{Jean F.\} and Krzysztof Bujko and Luca Cionini and Gerard, \{Jean P.\} and Claus R{\"o}del and Aldo Sainato and Rolf Sauer and Minsky, \{Bruce D.\} and Laurence Collette and Philippe Lambin",

year = "2015",

doi = "10.1016/j.radonc.2015.02.001",

language = "English",

volume = "114",

pages = "302--309",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

}

Valentini, V, Van Stiphout, RGPM, Lammering, G, Gambacorta, MA, Barba, MC, Bebenek, M, Bonnetain, F, Bosset, JF, Bujko, K, Cionini, L, Gerard, JP, Rödel, C, Sainato, A, Sauer, R, Minsky, BD, Collette, L & Lambin, P 2015, 'Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer', Radiotherapy and Oncology, vol. 114, pagg. 302-309. https://doi.org/10.1016/j.radonc.2015.02.001

TY - JOUR

T1 - Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

AU - Valentini, Vincenzo

AU - Van Stiphout, Ruud G.P.M.

AU - Lammering, Guido

AU - Gambacorta, Maria Antonietta

AU - Barba, Maria C.

AU - Bebenek, Marek

AU - Bonnetain, Franck

AU - Bosset, Jean F.

AU - Bujko, Krzysztof

AU - Cionini, Luca

AU - Gerard, Jean P.

AU - Rödel, Claus

AU - Sainato, Aldo

AU - Sauer, Rolf

AU - Minsky, Bruce D.

AU - Collette, Laurence

AU - Lambin, Philippe

PY - 2015

Y1 - 2015

N2 - Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.

AB - Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.

KW - Disease-free survival

KW - Pathological complete response

KW - Personalized treatment

KW - Prediction models

KW - Rectal cancer

KW - Risk ratio

KW - Disease-free survival

KW - Pathological complete response

KW - Personalized treatment

KW - Prediction models

KW - Rectal cancer

KW - Risk ratio

UR - http://hdl.handle.net/10807/66966

U2 - 10.1016/j.radonc.2015.02.001

DO - 10.1016/j.radonc.2015.02.001

M3 - Article

SN - 0167-8140

VL - 114

SP - 302

EP - 309

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Abstract

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Keywords

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