Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Vincenzo Valentini; Rgpm Van Stiphout; G Lammering; Maria Antonietta Gambacorta; Maria Cristina Barba; M Bebenek; F Bonnetain; Jf Bosset; K Bujko; L Cionini; Jp Gerard; C Rödel; A Sainato; R Sauer; Bd Minsky; L Collette; P. Lambin

doi:10.1016/j.radonc.2015.02.001

Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Vincenzo Valentini
, Rgpm Van Stiphout^*
, G Lammering
, Maria Antonietta Gambacorta
, Maria Cristina Barba
, M Bebenek
, F Bonnetain
, Jf Bosset
, K Bujko
, L Cionini
, Jp Gerard
, C Rödel
, A Sainato
, R Sauer
, Bd Minsky
, L Collette
, P. Lambin

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

30 Citazioni (Scopus)

Abstract

Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.

Lingua originale	Inglese
pagine (da-a)	302-309
Numero di pagine	8
Rivista	Radiotherapy and Oncology
Volume	114
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/j.radonc.2015.02.001
Stato di pubblicazione	Pubblicato - 2015

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Ematologia
Oncologia
Radiologia, Medicina Nucleare e Diagnostica per Immagini

Keywords

80 and over
Adjuvant
Adult
Aged
Biological
Chemotherapy
Combined Modality Therapy
Disease-Free Survival
Disease-free survival
Endpoint Determination
Female
Humans
Individualized Medicine
Local
Male
Middle Aged
Models
Neoplasm Recurrence
Pathological complete response
Personalized treatment
Prediction models
Prognosis
Randomized Controlled Trials as Topic
Rectal Neoplasms
Rectal cancer
Risk ratio
Statistical
Young Adult

Accesso al documento

10.1016/j.radonc.2015.02.001

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Valentini, V., Van Stiphout, R., Lammering, G., Gambacorta, M. A., Barba, M. C., Bebenek, M., Bonnetain, F., Bosset, J., Bujko, K., Cionini, L., Gerard, J., Rödel, C., Sainato, A., Sauer, R., Minsky, B., Collette, L., & Lambin, P. (2015). Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer. Radiotherapy and Oncology, 114(3), 302-309. https://doi.org/10.1016/j.radonc.2015.02.001

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title = "Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer",

abstract = "Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.",

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author = "Vincenzo Valentini and \{Van Stiphout\}, Rgpm and G Lammering and Gambacorta, \{Maria Antonietta\} and Barba, \{Maria Cristina\} and M Bebenek and F Bonnetain and Jf Bosset and K Bujko and L Cionini and Jp Gerard and C R{\"o}del and A Sainato and R Sauer and Bd Minsky and L Collette and P. Lambin",

year = "2015",

doi = "10.1016/j.radonc.2015.02.001",

language = "English",

volume = "114",

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journal = "Radiotherapy and Oncology",

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Valentini, V, Van Stiphout, R, Lammering, G, Gambacorta, MA, Barba, MC, Bebenek, M, Bonnetain, F, Bosset, J, Bujko, K, Cionini, L, Gerard, J, Rödel, C, Sainato, A, Sauer, R, Minsky, B, Collette, L & Lambin, P 2015, 'Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer', Radiotherapy and Oncology, vol. 114, n. 3, pagg. 302-309. https://doi.org/10.1016/j.radonc.2015.02.001

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AU - Valentini, Vincenzo

AU - Van Stiphout, Rgpm

AU - Lammering, G

AU - Gambacorta, Maria Antonietta

AU - Barba, Maria Cristina

AU - Bebenek, M

AU - Bonnetain, F

AU - Bosset, Jf

AU - Bujko, K

AU - Cionini, L

AU - Gerard, Jp

AU - Rödel, C

AU - Sainato, A

AU - Sauer, R

AU - Minsky, Bd

AU - Collette, L

AU - Lambin, P.

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KW - Chemotherapy

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KW - Individualized Medicine

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KW - Prediction models

KW - Prognosis

KW - Randomized Controlled Trials as Topic

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KW - Rectal cancer

KW - Risk ratio

KW - Statistical

KW - Young Adult

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U2 - 10.1016/j.radonc.2015.02.001

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M3 - Article

SN - 0167-8140

VL - 114

SP - 302

EP - 309

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

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