Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer

Vincenzo Valentini, Maria Antonietta Gambacorta, Maria Cristina Barba, Ruud G.P.M. Van Stiphout, Guido Lammering, Marek Bebenek, Franck Bonnetain, Jean F. Bosset, Krzysztof Bujko, Luca Cionini, Jean P. Gerard, Claus Rödel, Aldo Sainato, Rolf Sauer, Bruce D. Minsky, Laurence Collette, Philippe Lambin

Risultato della ricerca: Contributo in rivistaArticolo in rivista

29 Citazioni (Scopus)

Abstract

Personalized treatments based on predictions for patient outcome require early characterization of a rectal cancer patient's sensitivity to treatment. This study has two aims: (1) identify the main patterns of recurrence and response to the treatments (2) evaluate pathologic complete response (pCR) and two-year disease-free survival (2yDFS) for overall survival (OS) and their potential to be relevant intermediate endpoints to predict.
Lingua originaleEnglish
pagine (da-a)302-309
Numero di pagine8
RivistaRadiotherapy and Oncology
Volume114
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Disease-Free Survival
  • Disease-free survival
  • Endpoint Determination
  • Female
  • Humans
  • Individualized Medicine
  • Male
  • Middle Aged
  • Models, Biological
  • Models, Statistical
  • Neoplasm Recurrence, Local
  • Pathological complete response
  • Personalized treatment
  • Prediction models
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Rectal Neoplasms
  • Rectal cancer
  • Risk ratio
  • Young Adult

Fingerprint Entra nei temi di ricerca di 'Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer'. Insieme formano una fingerprint unica.

Cita questo