Secondary malignancies of the uterine cervix: a potential diagnostic pitfall

Arnaldo Carbone, Gian Franco Zannoni, Valerio Gaetano Vellone, Marco Petrillo, Guido Fadda, Esther Rossi, Giovanni Scambia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)


The occurrence of a secondary malignancy in the uterine cervix is a very rare event. In the vast majority of cases, this secondary involvement concerns direct spread of a uterine malignancy to the cervix. However, cancer of the ovary, breast, stomach, gallbladder, pancreas and lung has been reported to metastasize to the uterine cervix by hematogenous route. In this context, secondary lesions of the uterine cervix, in particular those of non-epithelial and extra-genital origin, are sufficiently rare to be overlooked, which might result in inappropriate diagnosis with disappointing consequences in terms of treatment planning. We report a single-institution consecutive series of 144 cases of secondary malignancy of the uterine cervix, emphasizing the morphological and immunohistochemical criteria required to arrive at a correct final diagnosis. Secondary malignancies of the uterine cervix have a protean appearance and can present with a wide spectrum of symptoms. Almost invariably metastases to the cervix signal devastating spread to many different organs. Histopathology, as well as immunohistochemical features and close collaboration between clinicians and pathologists, is essential to arrive at a correct final diagnosis
Lingua originaleEnglish
pagine (da-a)23-29
Numero di pagine7
RivistaVirchows Archiv
Stato di pubblicazionePubblicato - 2013


  • metastases to uterine cervix


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