TY - GEN
T1 - Scientific information on mycotoxins and natural plant toxicants.
AU - Battilani, Paola
AU - Costa, L. G.
AU - Dossena, A.
AU - Gullino, M. L.
AU - Marchelli, R.
AU - Galaverna, G.
AU - Pietri, Amedeo
AU - Dall'Asta, C.
AU - Giorni, Paola
AU - Spadaro, D.
AU - Gualla, Alessia
PY - 2009
Y1 - 2009
N2 - Undesirable substances such as mycotoxins and natural toxicants can be present in plants
and derived products thereof. Depending on the nature and the concentration levels of the
compound, these might be of concern for human and/or animal health. Risk assessments on
the natural plant toxicant morphine in poppy seeds and the selected mycotoxins: alternaria
toxins, moniliformin, diacetoxyscirpenol, sterigmatocystin and phomopsins in food and feed,
ergot alkaloids in food and nivalenol in feed have not been carried out at the European level.
Therefore it is expected that the European Commission may ask EFSA to assess the risks to
human and animal health related to these substances in the near future. To carry out these
risk assessments to the highest standards and in an efficient way scientific background
information e.g. chemistry, occurrence, toxicokinetics and toxicity on these selected
mycotoxins and plant toxicant are needed. The project CFP/EFSA/CONTAM/2008/01
“Scientific information on mycotoxins and natural plant toxicants” reports this information in
the present report.
The report presents information regarding a plant toxicant, morphine, in poppy seeds, and
some mycotoxins, in particular Alternaria toxins in food and feed, Ergot alkaloids in food,
moniliformin in food and feed, nivalenol in feed, diacetoxyscirpenol in food and feed,
sterigmatocystin in food and feed and phomopsins in food and feed. After a short
introduction, fungi involved in the production of each specific mycotoxin are described.
Physico-chemical characteristics, biosynthesis and chemical analisis are then discussed for
all toxins. Occurrence data are presented, taking into account all products in which the
mycotoxins have been reported. Mitigation, intended as all actions that can be taken in the
pre- and post-harvest periods to reduce the contamination of the final products are
discussed. Pharmacokinetic aspects (absorption, distribution and excretion, metabolism and
carry-over), as well as toxicity (acute and chronic), are also discussed, based on available
information in animals and in humans. This report represents the state-of-the-art knowledge
on the toxic compounds included, and provides information useful to the scientific community
to face the risks and challenges of mycotoxins and plant natural toxicants.
3 - 467
The present document has been produced and adopted by the bodies identified above as author(s). In accordance with Article
36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the author(s) in the context of a grant
agreement between the European Food Safety Authority and the author(s). The present document is published complying with
the transparency principle to which the European Food Safety Authority is subject. It may not be considered as an output
adopted by EFSA. EFSA reserves its rights, view and position as regards the issues addressed and the conclusions reached in
the present document, without prejudice to the rights of the authors.
As a general conclusion it can be underlined that for all compounds considered there is a
common lack of knowledge which can be summarised as follows:
• Detailed knowledge on fungi involved and their interaction with host crops
• Validated analytical methods and reference materials
• Detailed surveys in different countries and different years
• Specific sampling methods
• Detailed and updated knowledge on pharmacokinetics and toxicity
AB - Undesirable substances such as mycotoxins and natural toxicants can be present in plants
and derived products thereof. Depending on the nature and the concentration levels of the
compound, these might be of concern for human and/or animal health. Risk assessments on
the natural plant toxicant morphine in poppy seeds and the selected mycotoxins: alternaria
toxins, moniliformin, diacetoxyscirpenol, sterigmatocystin and phomopsins in food and feed,
ergot alkaloids in food and nivalenol in feed have not been carried out at the European level.
Therefore it is expected that the European Commission may ask EFSA to assess the risks to
human and animal health related to these substances in the near future. To carry out these
risk assessments to the highest standards and in an efficient way scientific background
information e.g. chemistry, occurrence, toxicokinetics and toxicity on these selected
mycotoxins and plant toxicant are needed. The project CFP/EFSA/CONTAM/2008/01
“Scientific information on mycotoxins and natural plant toxicants” reports this information in
the present report.
The report presents information regarding a plant toxicant, morphine, in poppy seeds, and
some mycotoxins, in particular Alternaria toxins in food and feed, Ergot alkaloids in food,
moniliformin in food and feed, nivalenol in feed, diacetoxyscirpenol in food and feed,
sterigmatocystin in food and feed and phomopsins in food and feed. After a short
introduction, fungi involved in the production of each specific mycotoxin are described.
Physico-chemical characteristics, biosynthesis and chemical analisis are then discussed for
all toxins. Occurrence data are presented, taking into account all products in which the
mycotoxins have been reported. Mitigation, intended as all actions that can be taken in the
pre- and post-harvest periods to reduce the contamination of the final products are
discussed. Pharmacokinetic aspects (absorption, distribution and excretion, metabolism and
carry-over), as well as toxicity (acute and chronic), are also discussed, based on available
information in animals and in humans. This report represents the state-of-the-art knowledge
on the toxic compounds included, and provides information useful to the scientific community
to face the risks and challenges of mycotoxins and plant natural toxicants.
3 - 467
The present document has been produced and adopted by the bodies identified above as author(s). In accordance with Article
36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the author(s) in the context of a grant
agreement between the European Food Safety Authority and the author(s). The present document is published complying with
the transparency principle to which the European Food Safety Authority is subject. It may not be considered as an output
adopted by EFSA. EFSA reserves its rights, view and position as regards the issues addressed and the conclusions reached in
the present document, without prejudice to the rights of the authors.
As a general conclusion it can be underlined that for all compounds considered there is a
common lack of knowledge which can be summarised as follows:
• Detailed knowledge on fungi involved and their interaction with host crops
• Validated analytical methods and reference materials
• Detailed surveys in different countries and different years
• Specific sampling methods
• Detailed and updated knowledge on pharmacokinetics and toxicity
KW - alternaria toxins
KW - diacetoxyscirpenol
KW - ergot alkaloids
KW - feed
KW - food
KW - moniliform
KW - morphine
KW - mycotoxins
KW - natural plant toxicants
KW - nivalenol
KW - phomopsins
KW - scientific information
KW - sterigmatocystin
KW - alternaria toxins
KW - diacetoxyscirpenol
KW - ergot alkaloids
KW - feed
KW - food
KW - moniliform
KW - morphine
KW - mycotoxins
KW - natural plant toxicants
KW - nivalenol
KW - phomopsins
KW - scientific information
KW - sterigmatocystin
UR - http://hdl.handle.net/10807/12818
M3 - Other contribution
ER -