SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients

M Zen, E Fuzzi, D Astorri, F Saccon, R Padoan, L Ienna, G Cozzi, R Depascale, E Zanatta, M Gasparotto, F Benvenuti, S Bindoli, M Gatto, M Felicetti, Augusta Ortolan, D Campaniello, M Larosa, M Lorenzin, R Ramonda, P SfrisoF Schiavon, L Iaccarino, A Doria

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. Methods: Between April 9th and April 25th, 2020, after SARS-CoV-2 infection peak, a telephone survey investigating the impact of COVID-19 on patients with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), ANCA-associated vasculitis (AAV), and idiopathic inflammatory myopathies (IIM) was administered. Demographics, disease activity status, therapy, occupational exposure, and adherence to social distancing advise were also collected. Results: 916 patients (397 SLE, 182 AAV, 176 SSc, 111 RA, 50 IIM) completed the survey. 148 patients developed at least one symptom compatible with COVID-19 (cough 96, sore throat 64, fever 64, arthromyalgias 59, diarrhea 26, conjunctivitis 18, ageusia/hyposmia, 18). Among the 916 patients, 65 (7.1%) underwent SARS-CoV-2 nasopharyngeal swab (18 symptomatic and 47 asymptomatic), 2 (0.21%) tested positive, a proportion similar to that observed in the general population of the Veneto region. No deaths occurred. 31 patients (3.4%) withdrew ≥1 medication, mainly immunosuppressants or biologics. Adoption of social distancing was observed by 860 patients (93.9%), including 335 (36.6%) who adopted it before official lockdown. Conclusions: COVID-19 incidence seems to be similar in our cohort compared to the general population. Adherence to therapy and to social distancing advise was high.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Autoimmunity
Volume112
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • ANCA vasculitis
  • Idiopathic inflammatory myopathies
  • Systemic sclerosis
  • SARS-CoV-2
  • Systemic lupus erythematosus
  • Rheumatoid arthritis

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