Sarcopenia as the Biological Substrate of Physical Frailty

Francesco Landi, Riccardo Calvani, Matteo Cesari, Matteo Tosato, Anna Maria Martone, Roberto Bernabei, Graziano Onder, Emanuele Marzetti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

123 Citazioni (Scopus)


Physical function decreases with aging, which may result in adverse outcomes (eg, disability, loss of independence, institutionalization, death). Physical function impairment is a common trait of frailty and sarcopenia. These two conditions, albeit highly common, have not yet received a unique operational definition, which has impeded their implementation in standard practice. Here, we introduce a conceptual model in which sarcopenia is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. This conceptualization may open new venues for the design of interventions against physical frailty and promote the translation of findings to the clinical arena.
Lingua originaleEnglish
pagine (da-a)367-374
Numero di pagine8
RivistaClinics in Geriatric Medicine
Stato di pubblicazionePubblicato - 2015


  • Aging
  • Disability
  • Operationalization
  • Physical performance
  • Skeletal muscle


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