Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia

Graziano Onder, Roger A. Fielding, Bruno Vellas, William J. Evans, Shalender Bhasin, John E. Morley, Anne B. Newman, Gabor Abellan Van Kan, Sandrine Andrieu, Juergen Bauer, Denis Breuille, Tommy Cederholm, Julie Chandler, Capucine De Meynard, Lorenzo Donini, Tamara Harris, Aimo Kannt, Florence Keime Guibert, Dimitris Papanicolaou, Yves RollandDaniel Rooks, Cornel Sieber, Elisabeth Souhami, Sjors Verlaan, Mauro Zamboni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1574 Citazioni (Scopus)

Abstract

Sarcopenia, the age-associated loss of skeletal muscle mass and function, has considerable societal consequences for the development of frailty, disability, and health care planning. A group of geriatricians and scientists from academia and industry met in Rome, Italy, on November 18, 2009, to arrive at a consensus definition of sarcopenia. The current consensus definition was approved unanimously by the meeting participants and is as follows: Sarcopenia is defined as the age-associated loss of skeletal muscle mass and function. The causes of sarcopenia are multifactorial and can include disuse, altered endocrine function, chronic diseases, inflammation, insulin resistance, and nutritional deficiencies. Although cachexia may be a component of sarcopenia, the 2 conditions are not the same. The diagnosis of sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health. Sarcopenia should specifically be considered in patients who are bedridden, cannot independently rise from a chair, or who have a measured gait speed less that 1 m/s(-1). Patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions. A diagnosis of sarcopenia is consistent with a gait speed of less than 1 m·s(-1) and an objectively measured low muscle mass (eg, appendicular mass relative to ht(2) that is ≤ 7.23 kg/m(2) in men and ≤ 5.67 kg/m(2) in women). Sarcopenia is a highly prevalent condition in older persons that leads to disability, hospitalization, and death.
Lingua originaleEnglish
pagine (da-a)249-256
Numero di pagine8
RivistaJournal of the American Medical Directors Association
Volume12
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Aged, 80 and over
  • Consensus
  • Diagnostic Errors
  • Female
  • Humans
  • Internationality
  • Male
  • Middle Aged
  • Sarcopenia

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