TY - JOUR
T1 - Salvage total laryngectomy after conservation laryngeal surgery for recurrent laryngeal squamous cell carcinoma.
AU - De Virgilio, A.
AU - Greco, Antonio
AU - Bussu, Francesco
AU - Gallo, A.
AU - Rosati, Donatella
AU - Kim, S. H.
AU - Wang, C. C.
AU - Conte, M.
AU - Pagliuca, G.
AU - De Vincentiis, M.
PY - 2016
Y1 - 2016
N2 - The aim of the present study was to evaluate the oncological efficacy of salvage total laryngectomy in patients who had previously undergone supracricoid partial laryngectomy or transoral laser microsurgery for treatment of laryngeal squamous cell carcinoma. We retrospectively reviewed the medical, surgical and pathological records of 35 patients who underwent salvage total laryngectomy after recurrence of laryngeal cancer (following supracricoid partial laryngectomy or transoral laser microsurgery). Kaplan-Meier survival curves as well as univariate and multivariate analyses of prognostic factors were performed. No statistically significant differences were seen comparing the supracricoid partial laryngectomy group with the transoral laser microsurgery group for overall survival and disease-specific survival at 3 years (OS = 38% vs. 52%, p = 0.16; DSS = 40% vs. 61%, p = 0.057) or locoregional control at 2 years (LRC = 40% vs. 54%, p = 0.056). A trend indicating worse survival and locoregional control for supracricoid partial laryngectomy patients emerged. Preservation of the osteocartilaginous frame in transoral laser microsurgery could hypothetically result in better salvageability of anterior recurrences with extralaryngeal spread.
AB - The aim of the present study was to evaluate the oncological efficacy of salvage total laryngectomy in patients who had previously undergone supracricoid partial laryngectomy or transoral laser microsurgery for treatment of laryngeal squamous cell carcinoma. We retrospectively reviewed the medical, surgical and pathological records of 35 patients who underwent salvage total laryngectomy after recurrence of laryngeal cancer (following supracricoid partial laryngectomy or transoral laser microsurgery). Kaplan-Meier survival curves as well as univariate and multivariate analyses of prognostic factors were performed. No statistically significant differences were seen comparing the supracricoid partial laryngectomy group with the transoral laser microsurgery group for overall survival and disease-specific survival at 3 years (OS = 38% vs. 52%, p = 0.16; DSS = 40% vs. 61%, p = 0.057) or locoregional control at 2 years (LRC = 40% vs. 54%, p = 0.056). A trend indicating worse survival and locoregional control for supracricoid partial laryngectomy patients emerged. Preservation of the osteocartilaginous frame in transoral laser microsurgery could hypothetically result in better salvageability of anterior recurrences with extralaryngeal spread.
KW - Carcinoma
KW - Larynx
KW - Otorhinolaryngology2734 Pathology and Forensic Medicine
KW - Salvage total laryngectomy
KW - Supracricoid laryngectomy
KW - TRansoral laser microsurgery
KW - Carcinoma
KW - Larynx
KW - Otorhinolaryngology2734 Pathology and Forensic Medicine
KW - Salvage total laryngectomy
KW - Supracricoid laryngectomy
KW - TRansoral laser microsurgery
UR - https://publicatt.unicatt.it/handle/10807/93000
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85003486015&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003486015&origin=inward
U2 - 10.14639/0392-100X-749
DO - 10.14639/0392-100X-749
M3 - Article
SN - 0392-100X
VL - 36
SP - 373
EP - 380
JO - Acta Otorhinolaryngologica Italica
JF - Acta Otorhinolaryngologica Italica
IS - 5
ER -