Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease?

Massimo Castagnola, Na Tian, Irene Messana, Daniel A. Leffler, Ciaran P. Kelly, Joshua Hansen, Tiziana Cabras, Alfredo D'Alessandro, Detlef Schuppan, Eva J. Helmerhorst

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

Gluten proteins, the culprits in celiac disease (CD), show striking similarities in primary structure with human salivary proline-rich proteins (PRPs). Both are enriched in proline and glutamine residues that often occur consecutively in their sequences. We investigated potential differences in the spectrum of salivary PRPs in health and CD.
Lingua originaleEnglish
pagine (da-a)953-964
Numero di pagine12
RivistaPROTEOMICS. CLINICAL APPLICATIONS
Volume9
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Celiac disease
  • Gliadin
  • Proline-rich protein
  • Saliva

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