Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease

Paolo Bartolomeo, A Bachoud Lévi, C Bourdet, P Brugières, Jp Nguyen, T Grandmougin, B Haddad, R Jény, Mf Boissé, Gd Barba, Jd Degos, Am Ergis, Jp Lefaucheur, F Lisovoski, E Pailhous, P Rémy, S Palfi, Gl Defer, Pierre Cesaro, P HantrayeM. Peschanski

Risultato della ricerca: Contributo in rivistaArticolo in rivista

131 Citazioni (Scopus)

Abstract

This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual "safety" follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.
Lingua originaleEnglish
pagine (da-a)194-202
Numero di pagine9
RivistaExperimental Neurology
Volume161
DOI
Stato di pubblicazionePubblicato - 2000

Keywords

  • Adult
  • Brain Tissue Transplantation
  • Cognition
  • Corpus Striatum
  • Cyclosporine
  • Family
  • Female
  • Follow-Up Studies
  • Humans
  • Huntington Disease
  • Immunosuppressive Agents
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Postoperative Care
  • Preoperative Care
  • Safety
  • Treatment Outcome

Fingerprint

Entra nei temi di ricerca di 'Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease'. Insieme formano una fingerprint unica.

Cita questo