TY - JOUR
T1 - Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production.
AU - Zuppa, Antonio Alberto
AU - Sindico, Paola
AU - Orchi, Claudia
AU - Carducci, Chiara
AU - Cardiello, Valentina
AU - Romagnoli, Costantino
PY - 2010
Y1 - 2010
N2 - Poor production of breast milk is the most frequent cause of breast lactation
failure. Often, physician prescribe medications or other substances to solve this
problem. The use of galactogogues should be limited to those situations in which
reduced milk production from treatable causes has been excluded. One of the most
frequent indication for the use of galactogogues is the diminution of milk
production in mothers using indirect lactation, particularly in the case of
preterm birth. The objective of this review is to analyze to the literature
relating to the principal drugs used as galactogogues (metoclopramide,
domperidone, chlorpromazine, sulpiride, oxytocin, growth hormone, thyrotrophin
releasing hormone, medroxyprogesterone). Have been also analyzed galactogogues
based on herbs and other natural substances (fenugreek, galega and milk thistle).
We have evaluated their mechanism of action, transfer to maternal milk,
effectiveness and potential side effects for mother and infant, suggested doses
for galactogogic effect, and recommendation for breastfeeding.
AB - Poor production of breast milk is the most frequent cause of breast lactation
failure. Often, physician prescribe medications or other substances to solve this
problem. The use of galactogogues should be limited to those situations in which
reduced milk production from treatable causes has been excluded. One of the most
frequent indication for the use of galactogogues is the diminution of milk
production in mothers using indirect lactation, particularly in the case of
preterm birth. The objective of this review is to analyze to the literature
relating to the principal drugs used as galactogogues (metoclopramide,
domperidone, chlorpromazine, sulpiride, oxytocin, growth hormone, thyrotrophin
releasing hormone, medroxyprogesterone). Have been also analyzed galactogogues
based on herbs and other natural substances (fenugreek, galega and milk thistle).
We have evaluated their mechanism of action, transfer to maternal milk,
effectiveness and potential side effects for mother and infant, suggested doses
for galactogogic effect, and recommendation for breastfeeding.
KW - galattogogues
KW - galattogogues
UR - http://hdl.handle.net/10807/21019
M3 - Article
SN - 1482-1826
SP - 162
EP - 174
JO - JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES
JF - JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES
ER -