Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial

C Rosso Fernández; J Garnacho Montero; Massimo Antonelli; G Dimopoulos; Jm Cisneros

doi:10.1186/s13063-015-0614-4

Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial

C Rosso Fernández, J Garnacho Montero, Massimo Antonelli, G Dimopoulos, Jm Cisneros

Risultato della ricerca: Contributo in rivista › Articolo

13 Citazioni (Scopus)

Abstract

Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, is now the antimicrobial with greatest in vitro activity against MDR-GNB.

Lingua originale	Inglese
pagine (da-a)	102-102
Numero di pagine	1
Rivista	Trials
Volume	16
Numero di pubblicazione	Marzo
DOI	https://doi.org/10.1186/s13063-015-0614-4
Stato di pubblicazione	Pubblicato - 2015

All Science Journal Classification (ASJC) codes

Medicina (varie)
Farmacologia (medica)

Keywords

Anti-Bacterial Agents
Bacterial
Clinical Protocols
Colistin
Drug Resistance
Europe
Gram-Negative Bacterial Infections
Humans
Incidence
Multiple
Patents as Topic
Pneumonia
Research Design
Thienamycins
Time Factors
Treatment Outcome
Ventilator-Associated

Accesso al documento

10.1186/s13063-015-0614-4

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Rosso Fernández, C., Garnacho Montero, J., Antonelli, M., Dimopoulos, G., & Cisneros, J. (2015). Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial. Trials, 16(Marzo), 102-102. https://doi.org/10.1186/s13063-015-0614-4

Rosso Fernández, C ; Garnacho Montero, J ; Antonelli, Massimo et al. / Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial. In: Trials. 2015 ; Vol. 16, N. Marzo. pagg. 102-102.

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title = "Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial",

abstract = "Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, is now the antimicrobial with greatest in vitro activity against MDR-GNB.",

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year = "2015",

doi = "10.1186/s13063-015-0614-4",

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Rosso Fernández, C, Garnacho Montero, J, Antonelli, M, Dimopoulos, G & Cisneros, J 2015, 'Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial', Trials, vol. 16, n. Marzo, pagg. 102-102. https://doi.org/10.1186/s13063-015-0614-4

Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial. / Rosso Fernández, C; Garnacho Montero, J; Antonelli, Massimo et al.
In: Trials, Vol. 16, N. Marzo, 2015, pag. 102-102.

Risultato della ricerca: Contributo in rivista › Articolo

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Rosso Fernández C, Garnacho Montero J, Antonelli M, Dimopoulos G, Cisneros J. Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial. Trials. 2015;16(Marzo):102-102. doi: 10.1186/s13063-015-0614-4