Safety and efficacy of baclofen in the treatment of alcohol-dependent patients.

Giovanni Addolorato, Lorenzo Leggio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

76 Citazioni (Scopus)


Preclinical studies show that antagonism of the GABA(B) receptor may represent an effective neuropharmacological approach to treat alcohol dependence. Consistent with preclinical evidence, the majority of the human studies have demonstrated that the prototype GABA(B) receptor antagonist baclofen may represent an effective mediation to treat alcohol-dependent individuals. Specifically, baclofen has shown to reduce alcohol withdrawal symptoms, as well as to reduce alcohol craving and intake, and to promote alcohol abstinence. Notably, baclofen has shown a safe profile when administered to alcoholics, including those with liver cirrhosis. In summary, baclofen represents a safe and effective medication to treat alcohol dependence, thus holding promise as a new pharmacotherapy. However, large studies are needed to confirm the present findings.
Lingua originaleEnglish
pagine (da-a)2113-2117
Numero di pagine5
RivistaCurrent Pharmaceutical Design
Stato di pubblicazionePubblicato - 2010


  • alcohol-dependence
  • baclofen
  • efficacy
  • safety


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