Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial

Anna Rita Bentivoglio; Jean-Michel Gracies; Allison Brashear; Robert Jech; Peter Mcallister; Marta Banach; Peter Valkovic; Heather Walker; Christina Marciniak; Thierry Deltombe; Alexander Skoromets; Svetlana Khatkova; Steven Edgley; Fatma Gul; France Catus; Beatrice Bois De Fer; Claire Vilain; Philippe Picaut; Z. Ayyoub; D. Bensmail; A. R Bentivoglio; F. Boyer; A. Csanyi; Z. Denes; P. Hedera; S. Isaacson; M. E. Isner-Horobeti; A. Kaminska; S. Kocer; T. Lejeune; P. Marque; M. O'Dell; O. Remy-Neris; B. Rubin; M. Rudzinska; D. Simpson; S. L. Timerbaeva; M. Vecchio; M. Wimmer

doi:10.1016/S1474-4422(15)00216-1

Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial

Anna Rita Bentivoglio, Jean-Michel Gracies, Allison Brashear, Robert Jech, Peter Mcallister, Marta Banach, Peter Valkovic, Heather Walker, Christina Marciniak, Thierry Deltombe, Alexander Skoromets, Svetlana Khatkova, Steven Edgley, Fatma Gul, France Catus, Beatrice Bois De Fer, Claire Vilain, Philippe Picaut, Z. Ayyoub, D. BensmailA. R Bentivoglio, F. Boyer, A. Csanyi, Z. Denes, P. Hedera, S. Isaacson, M. E. Isner-Horobeti, A. Kaminska, S. Kocer, T. Lejeune, P. Marque, M. O'Dell, O. Remy-Neris, B. Rubin, M. Rudzinska, D. Simpson, S. L. Timerbaeva, M. Vecchio, M. Wimmer

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Abstract

Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the effects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and function.

Lingua originale	English
pagine (da-a)	992-1001
Numero di pagine	10
Rivista	The Lancet
Volume	14
DOI	https://doi.org/10.1016/S1474-4422(15)00216-1
Stato di pubblicazione	Pubblicato - 2015

Keywords

Acetylcholine Release Inhibitors
Adult
Botulinum Toxins, Type A
Brain Injuries
Double-Blind Method
Female
Humans
Injections, Intramuscular
Male
Middle Aged
Muscle Spasticity
Paresis
Stroke
Treatment Outcome
Upper Extremity

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10.1016/S1474-4422(15)00216-1

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Bentivoglio, A. R., Gracies, J-M., Brashear, A., Jech, R., Mcallister, P., Banach, M., Valkovic, P., Walker, H., Marciniak, C., Deltombe, T., Skoromets, A., Khatkova, S., Edgley, S., Gul, F., Catus, F., De Fer, B. B., Vilain, C., Picaut, P., Ayyoub, Z., ... Wimmer, M. (2015). Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial. The Lancet, 14, 992-1001. https://doi.org/10.1016/S1474-4422(15)00216-1

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title = "Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial",

abstract = "Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the effects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and function.",

keywords = "Acetylcholine Release Inhibitors, Adult, Botulinum Toxins, Type A, Brain Injuries, Double-Blind Method, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Muscle Spasticity, Paresis, Stroke, Treatment Outcome, Upper Extremity, Acetylcholine Release Inhibitors, Adult, Botulinum Toxins, Type A, Brain Injuries, Double-Blind Method, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Muscle Spasticity, Paresis, Stroke, Treatment Outcome, Upper Extremity",

author = "Bentivoglio, {Anna Rita} and Jean-Michel Gracies and Allison Brashear and Robert Jech and Peter Mcallister and Marta Banach and Peter Valkovic and Heather Walker and Christina Marciniak and Thierry Deltombe and Alexander Skoromets and Svetlana Khatkova and Steven Edgley and Fatma Gul and France Catus and {De Fer}, {Beatrice Bois} and Claire Vilain and Philippe Picaut and Z. Ayyoub and D. Bensmail and {R Bentivoglio}, A. and F. Boyer and A. Csanyi and Z. Denes and P. Hedera and S. Isaacson and Isner-Horobeti, {M. E.} and A. Kaminska and S. Kocer and T. Lejeune and P. Marque and M. O'Dell and O. Remy-Neris and B. Rubin and M. Rudzinska and D. Simpson and Timerbaeva, {S. L.} and M. Vecchio and M. Wimmer",

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doi = "10.1016/S1474-4422(15)00216-1",

language = "English",

volume = "14",

pages = "992--1001",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Lancet Limited:42 Bedford Square, London WC1B 3SL United Kingdom:011 44 207 4364981, EMAIL: custserv@lancet.com, INTERNET: http://www.thelancet.com, Fax: 011 44 207 3236433",

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Bentivoglio, AR, Gracies, J-M, Brashear, A, Jech, R, Mcallister, P, Banach, M, Valkovic, P, Walker, H, Marciniak, C, Deltombe, T, Skoromets, A, Khatkova, S, Edgley, S, Gul, F, Catus, F, De Fer, BB, Vilain, C, Picaut, P, Ayyoub, Z, Bensmail, D, R Bentivoglio, A, Boyer, F, Csanyi, A, Denes, Z, Hedera, P, Isaacson, S, Isner-Horobeti, ME, Kaminska, A, Kocer, S, Lejeune, T, Marque, P, O'Dell, M, Remy-Neris, O, Rubin, B, Rudzinska, M, Simpson, D, Timerbaeva, SL, Vecchio, M & Wimmer, M 2015, 'Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial', The Lancet, vol. 14, pagg. 992-1001. https://doi.org/10.1016/S1474-4422(15)00216-1

TY - JOUR

T1 - Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial

AU - Bentivoglio, Anna Rita

AU - Gracies, Jean-Michel

AU - Brashear, Allison

AU - Jech, Robert

AU - Mcallister, Peter

AU - Banach, Marta

AU - Valkovic, Peter

AU - Walker, Heather

AU - Marciniak, Christina

AU - Deltombe, Thierry

AU - Skoromets, Alexander

AU - Khatkova, Svetlana

AU - Edgley, Steven

AU - Gul, Fatma

AU - Catus, France

AU - De Fer, Beatrice Bois

AU - Vilain, Claire

AU - Picaut, Philippe

AU - Ayyoub, Z.

AU - Bensmail, D.

AU - R Bentivoglio, A.

AU - Boyer, F.

AU - Csanyi, A.

AU - Denes, Z.

AU - Hedera, P.

AU - Isaacson, S.

AU - Isner-Horobeti, M. E.

AU - Kaminska, A.

AU - Kocer, S.

AU - Lejeune, T.

AU - Marque, P.

AU - O'Dell, M.

AU - Remy-Neris, O.

AU - Rubin, B.

AU - Rudzinska, M.

AU - Simpson, D.

AU - Timerbaeva, S. L.

AU - Vecchio, M.

AU - Wimmer, M.

PY - 2015

Y1 - 2015

N2 - Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the effects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and function.

AB - Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the effects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and function.

KW - Acetylcholine Release Inhibitors

KW - Adult

KW - Botulinum Toxins, Type A

KW - Brain Injuries

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Injections, Intramuscular

KW - Male

KW - Middle Aged

KW - Muscle Spasticity

KW - Paresis

KW - Stroke

KW - Treatment Outcome

KW - Upper Extremity

KW - Acetylcholine Release Inhibitors

KW - Adult

KW - Botulinum Toxins, Type A

KW - Brain Injuries

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Injections, Intramuscular

KW - Male

KW - Middle Aged

KW - Muscle Spasticity

KW - Paresis

KW - Stroke

KW - Treatment Outcome

KW - Upper Extremity

UR - http://hdl.handle.net/10807/69797

U2 - 10.1016/S1474-4422(15)00216-1

DO - 10.1016/S1474-4422(15)00216-1

M3 - Article

VL - 14

SP - 992

EP - 1001

JO - The Lancet

JF - The Lancet

SN - 0140-6736

ER -

Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial

Abstract

Keywords

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