S100B PROTEIN LEVELS IN SALIVA: CORRELATION WITH GESTATIONAL AGE IN NORMAL TERM AND PRETERM NEWBORNS

Diego Gazzolo; Mario Lituania; Matteo Bruschettini; Sabina Ciotti; Renata Sacchi; Giovanni Serra; Maria Grazia Calevo; Valentina Corvino; Giuseppe Buonocore; Fabrizio Michetti

S100B PROTEIN LEVELS IN SALIVA: CORRELATION WITH GESTATIONAL AGE IN NORMAL TERM AND PRETERM NEWBORNS

Diego Gazzolo, Mario Lituania, Matteo Bruschettini, Sabina Ciotti, Renata Sacchi, Giovanni Serra, Maria Grazia Calevo, Valentina Corvino, Giuseppe Buonocore, Fabrizio Michetti

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

34 Citazioni (Scopus)

Abstract

OBJECTIVES: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. DESIGN AND METHODS: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. RESULTS: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P < 0.001). CONCLUSIONS: The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels.

Lingua originale	English
pagine (da-a)	229-233
Numero di pagine	5
Rivista	Clinical Biochemistry
Stato di pubblicazione	Pubblicato - 2005

Keywords

S100B protein
saliva

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title = "S100B PROTEIN LEVELS IN SALIVA: CORRELATION WITH GESTATIONAL AGE IN NORMAL TERM AND PRETERM NEWBORNS",

abstract = "OBJECTIVES: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. DESIGN AND METHODS: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. RESULTS: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P < 0.001). CONCLUSIONS: The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels.",

keywords = "S100B protein, saliva, S100B protein, saliva",

author = "Diego Gazzolo and Mario Lituania and Matteo Bruschettini and Sabina Ciotti and Renata Sacchi and Giovanni Serra and Calevo, {Maria Grazia} and Valentina Corvino and Giuseppe Buonocore and Fabrizio Michetti",

year = "2005",

language = "English",

pages = "229--233",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - S100B PROTEIN LEVELS IN SALIVA: CORRELATION WITH GESTATIONAL AGE IN NORMAL TERM AND PRETERM NEWBORNS

AU - Gazzolo, Diego

AU - Lituania, Mario

AU - Bruschettini, Matteo

AU - Ciotti, Sabina

AU - Sacchi, Renata

AU - Serra, Giovanni

AU - Calevo, Maria Grazia

AU - Corvino, Valentina

AU - Buonocore, Giuseppe

AU - Michetti, Fabrizio

PY - 2005

Y1 - 2005

N2 - OBJECTIVES: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. DESIGN AND METHODS: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. RESULTS: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P < 0.001). CONCLUSIONS: The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels.

AB - OBJECTIVES: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. DESIGN AND METHODS: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. RESULTS: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P < 0.001). CONCLUSIONS: The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels.

KW - S100B protein

KW - saliva

KW - S100B protein

KW - saliva

UR - http://hdl.handle.net/10807/6046

M3 - Article

SN - 0009-9120

SP - 229

EP - 233

JO - Clinical Biochemistry

JF - Clinical Biochemistry

ER -

S100B PROTEIN LEVELS IN SALIVA: CORRELATION WITH GESTATIONAL AGE IN NORMAL TERM AND PRETERM NEWBORNS

Abstract

Keywords

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