S100B protein is increased in asphyxiated term infants developing intraventricular hemorrhage.

Fabrizio Michetti, Diego Gazzolo, Romolo Di Iorio, Emanuela Marinoni, Paolo Masetti, Giovanni Serra, Lia Giovannini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

67 Citazioni (Scopus)

Abstract

OBJECTIVE: To establish whether S100B protein may be useful in the early detection of intraventricular hemorrhage in asphyxiated term infants. DESIGN: Case-control study. PATIENTS: Twenty full-term newborns with intraventricular hemorrhage, 20 asphyxiated infants without intraventricular hemorrhage, and 80 normal newborns. INTERVENTIONS: Routine laboratory variables and neurologic patterns were assessed at birth after 12 and 72 hrs. Ultrasound imaging and middle cerebral artery Doppler velocimetry pulsatility index were recorded at 12 and 72 hrs after birth. S100B protein blood concentrations were determined at 12 hrs. MEASUREMENTS AND MAIN RESULTS: S100B protein levels were significantly higher in samples collected from newborns who developed intraventricular hemorrhage (1.87 +/- 0.60 microg/L) than from those who did not develop intraventricular hemorrhage (0.72 +/- 0.39 microg/L) or from normal infants (0.66 +/- 0.31 microg/L). Multiple logistic regression analysis showed a significant correlation between circulating S100B protein concentrations and the occurrence of intraventricular hemorrhage. CONCLUSIONS: This study suggests that elevated S100B protein represents a useful tool for the early detection of intraventricular hemorrhage in the postasphyxia period when clinical examination and cerebral ultrasound might still be silent.
Lingua originaleEnglish
pagine (da-a)1356-1360
Numero di pagine5
RivistaCritical Care Medicine
Stato di pubblicazionePubblicato - 2002

Keywords

  • Intraventricular Hemorrhage
  • S100B

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