Rosai-Dorfman Disease. Two Case Report and Diagnostic Role of Fine-Needle Aspiration Cytology.

Antonio Ruggiero, Palma Maurizi, Elisabetta Tarquini, Giuseppe Barone, Ilaria Lazzareschi, Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)


Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and self-limiting benign disorder that most commonly involves the cervical lymph nodes. The authors describe two cases of SHML. Fine-needle aspiration of the lymphadenopathy was performed in both patients. Immunocytochemical and histologic features, as the evidence of emperipolesis and S100 protein positivity on immunostaining, were typical of SHML. Fine-needle aspiration cytology plays an important diagnostic role in SHML and may be conclusive in a typical clinical setting. The diagnosis of SHML should be considered in the differential diagnosis of massive, painless cervical lymphadenopathy. Long-term follow-up is necessary to observe the complete regression of the massive lymphadenopathy. However, specific therapy is available and should be limited to patients with compressive symptoms or extranodal disease.
Lingua originaleEnglish
pagine (da-a)103-106
Numero di pagine4
Stato di pubblicazionePubblicato - 2006


  • Rosai-Dorfman Disease
  • children
  • fine-needle aspiration cytology
  • lymphadenopathy
  • massive lymphadenopathy
  • sinus histiocytosis


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