Role of troponin in COVID-19 pandemic: A review of literature

Andrea Piccioni, M. Brigida, Valentina Loria, C. Zanza, Christian Zanza, Y. Longhitano, R. Zaccaria, S. Racco, Antonio Gasbarrini, Veronica Ojetti, Francesco Franceschi, Marcello Candelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Acute SARS-CoV-2 respiratory disease is an infectious respiratory disease caused by the virus SARS-CoV-2 belonging to the coronaviridae family. A pandemic is still present as of May 2020. In addition to causing pneumonia, SARS-CoV-2 may induce a direct damage to the heart, causing myocarditis, with significant impairment of cardiac contractility, and/or pericarditis. Elderly patients and those with cardiovascular risk factors, such as hypertension and diabetes mellitus, are at increased risk of heart complications from COVID-19. In this review, we focused on the correlation between COVID-19 infection and the high sensitivity troponin T and I, and their significance in the development of myocarditis. Data emerging from the studies so far conducted indicate that a high value of high-sensitivity troponin represents a negative prognostic indicator when associated with heart damage on an infectious-inflammatory basis (i.e. myopericarditis). We should identify a safe and clear diagnostic algorithm, possibly combining patient clinical history, troponin levels and cardiac ultrasound findings that could help us in the prediction of myopericarditis.
Lingua originaleEnglish
pagine (da-a)10293-10300
Numero di pagine8
RivistaEuropean Review for Medical and Pharmacological Sciences
Stato di pubblicazionePubblicato - 2020


  • COVID-19
  • Emergency Department
  • Humans
  • Myocarditis
  • Pandemic
  • Pandemics
  • Pericarditis
  • Prognosis
  • SARS-CoV-2
  • Troponin
  • Troponin I
  • Troponin T


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