Role of the complement in pregnancy with antiphospholipid syndrome: Mechanisms of pathogenesis and clinical aspects

Sara De Carolis, Serafina Garofalo, Silvia Salvi, Angela Botta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Antiphospholipid syndrome is a disease that was discovered just 25 years ago. Although clinical manifestations have been clearly described, pathogenetic mechanisms are still barely understood. A recent hypothesis involves inflammation in the setting of antiphospholipid syndrome morbidity and experimental data support the activation of a complement cascade as a pivotal event in its physiopathology. In this review, the authors will analyze the recent literature, focusing on contemporary and emerging aspects of complement-mediated disease pathogenesis, and pinpoint the clinical significance of this novel finding. © 2013 Future Medicine Ltd.
Lingua originaleEnglish
pagine (da-a)399-405
Numero di pagine7
RivistaInternational Journal of Clinical Rheumatology
Volume8
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • adverse pregnancy outcome
  • antiphospholipid syndrome
  • complement pathway
  • hypocomplementemia

Fingerprint Entra nei temi di ricerca di 'Role of the complement in pregnancy with antiphospholipid syndrome: Mechanisms of pathogenesis and clinical aspects'. Insieme formano una fingerprint unica.

Cita questo