Role of spiramycin/cotrimoxazole association in the mother-to-child transmission of toxoplasmosis infection in pregnancy.

Piero Valentini, Lucia Masini, Marco De Santis, Antonia Carla Testa, Donatella Francesca Angelone, Rita Luciana Grillo, Domenico Speziale, Orazio Gaetano Ranno, Ml Annunziata

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The purpose of this report is to evaluate the efficacy and safety of spiramycin/cotrimoxazole in the mother-to-child transmission of Toxoplasma gondii infection. We retrospectively analysed 76 infants born to mothers with toxoplasmosis during pregnancy and estimated the risk of mother-to-child transmission considering the gestational age at the time of infection. Seventy-six mothers were given spiramycin, cotrimoxazole and folinic acid; only two babies (2.6%) were infected by Toxoplasma and none of them showed signs or symptoms of congenital infection or interference of sulphamid on tetrahydrofolate reductase (THFR) either at birth or during follow-up. Treatment did not need to be stopped in any mother because of adverse drug effects. Our results seem to encourage the use of spiramycin/cotrimoxazole in women with toxoplasmosis during pregnancy
Lingua originaleEnglish
pagine (da-a)297-300
Numero di pagine4
RivistaEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Stato di pubblicazionePubblicato - 2009

Keywords

  • pregnancy.
  • spiramycin/cotrimoxazole.
  • toxoplasmosis

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