Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patients affected by prostate cancer: preliminary results

Francesco Pierconti, Emilio Sacco, Pierfrancesco Bassi, Alessandro Calarco, Francesco Pinto, Eleonora Marrucci, Angelo Totaro, Giuseppe Palermo, Matteo Vittori

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

Chronic inflammation may play a role in prostate carcinogenesis. Molecular alterations of the Suppressor of Cytokine Signaling (SOCS)-3 can contribute to explain the pleiotropic role of interleukin (IL)-6 in this type of cancer. Recently, the methylation of SOCS3 gene has been demonstrated to cause the non-expression of the protein, being involved in the pathogenesis of prostate cancer (PC) and identifying a subset of aggressive tumors. We evaluated the expression of SOCS3 protein in patients (pt) with bioptically-diagnosed PC by immunohistochemical analysis, which is easier to perform, cheaper and more reproducible compared to DNA analysis.
Lingua originaleEnglish
pagine (da-a)4-8
Numero di pagine5
RivistaUrologia
Volume79 Suppl 19
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • prostate cancer

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