Role of microRNA in response to ionizing radiations: evidences and potential impact on clinical practice for radiotherapy

Vincenzo Valentini, Francesco Cellini, Alessio Giuseppe Morganti, Domenico Genovesi, Nicola Silvestris

Risultato della ricerca: Contributo in rivistaArticolo in rivista

49 Citazioni (Scopus)

Abstract

MicroRNAs (miRNA) are small, non-coding, RNAs with gene expression regulator roles. As an important class of regulators of many cellular pathways, miRNAs are involved in many signaling pathways and DNA damage repair processes, affecting cellular radiosensitivity. Their role has led to interest in oncological implications to improve treatment results. MiRNAs represent a great opportunity to enhance the efficacy of radiotherapy treatments-they can be used to profile the radioresistance of tumors before radiotherapy, monitor their response throughout the treatment, thus helping to select intensification strategies, and also to define the final response to therapy along with risks of recurrence or metastatization. Even though many interesting studies support such potential, nowadays most studies on patient data are limited to experiments profiling tumor aggressiveness and response to radiotherapy. Moreover many studies report different although not conflicting results on the miRNAs evaluated for each tumor type. Without doubt, the clinical potential of such molecules for radiotherapy is striking and of high interest.
Lingua originaleEnglish
pagine (da-a)5379-5401
Numero di pagine23
RivistaMolecules
Volume19
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Animals
  • DNA Damage
  • DNA Repair
  • Humans
  • MicroRNAs
  • Neoplasms
  • Radiation Injuries
  • Radiation Tolerance
  • Signal Transduction

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