Role of lycopene in the control of ROS mediated cell growth. Implication in cancer prevention

Paola Palozza, Rossella Emanuela Simone, Assunta Catalano, Nadia Parrone

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

36 Citazioni (Scopus)

Abstract

Dietary intakes of tomatoes and tomato products containing lycopene have been shown to be associated with decreased risk of chronic diseases, such as cancer. Although several mechanisms, including modulation of gap junction communication and enhancement of immune system, are thought to be implicated in its beneficial activities, evidence is accumulating to suggest that lycopene may act as a modulator of intracellular reactive oxygen species (ROS) and, therefore, control ROS-mediated cell growth. According with this, at high concentration, ROS have been reported to be hazardous for living organisms, whereas at moderate concentrations, they play an important role as regulatory mediators in signalling processes regulating cell growth. In this review, we report the available evidence on a role of lycopene as a redox agent in cell proliferation, differentiation and apoptosis. In particular, we focused our attention on lycopene modulation of redox-sensitive targets in signalling cascades: receptor-mediated signalling pathways, protein tyrosine phosphatases, protein kinases, MAPK cascade, cytosolic calcium concentration, transcription factors, such as NF-kB and AP-1, glutathione levels. Moreover, we speculate on the possible influence that lycopene may have as a redox agent in human cancer.
Lingua originaleEnglish
pagine (da-a)1846-1860
Numero di pagine15
RivistaCURRENT MEDICINAL CHEMISTRY
Stato di pubblicazionePubblicato - 2011
Pubblicato esternamente

Keywords

  • ROS
  • animal studies
  • cancer
  • cell culture
  • cell growth
  • human tials
  • lycopene
  • oxidative damage
  • redox sensitive molecular pathways
  • tomato/tomato products

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