TY - JOUR
T1 - Role of lycopene in the control of ROS mediated cell growth. Implication in cancer prevention
AU - Palozza, Paola
AU - Simone, Rossella Emanuela
AU - Catalano, Assunta
AU - Parrone, Nadia
PY - 2011
Y1 - 2011
N2 - Dietary intakes of tomatoes and tomato products containing lycopene have been shown to be associated with decreased risk of chronic diseases, such as cancer. Although several mechanisms, including modulation of gap junction communication and enhancement of immune system, are thought to be implicated in its beneficial activities, evidence is accumulating to suggest that lycopene may act as a modulator of intracellular reactive oxygen species (ROS) and, therefore, control ROS-mediated cell growth. According with this, at high concentration, ROS have been reported to be hazardous for living organisms, whereas at moderate concentrations, they play an important role as regulatory mediators in signalling processes regulating cell growth. In this review, we report the available evidence on a role of lycopene as a redox agent in cell proliferation, differentiation and apoptosis. In particular, we focused our attention on lycopene modulation of redox-sensitive targets in signalling cascades: receptor-mediated signalling pathways, protein tyrosine phosphatases, protein kinases, MAPK cascade, cytosolic calcium concentration, transcription factors, such as NF-kB and AP-1, glutathione levels. Moreover, we speculate on the possible influence that lycopene may have as a redox agent in human cancer.
AB - Dietary intakes of tomatoes and tomato products containing lycopene have been shown to be associated with decreased risk of chronic diseases, such as cancer. Although several mechanisms, including modulation of gap junction communication and enhancement of immune system, are thought to be implicated in its beneficial activities, evidence is accumulating to suggest that lycopene may act as a modulator of intracellular reactive oxygen species (ROS) and, therefore, control ROS-mediated cell growth. According with this, at high concentration, ROS have been reported to be hazardous for living organisms, whereas at moderate concentrations, they play an important role as regulatory mediators in signalling processes regulating cell growth. In this review, we report the available evidence on a role of lycopene as a redox agent in cell proliferation, differentiation and apoptosis. In particular, we focused our attention on lycopene modulation of redox-sensitive targets in signalling cascades: receptor-mediated signalling pathways, protein tyrosine phosphatases, protein kinases, MAPK cascade, cytosolic calcium concentration, transcription factors, such as NF-kB and AP-1, glutathione levels. Moreover, we speculate on the possible influence that lycopene may have as a redox agent in human cancer.
KW - ROS
KW - animal studies
KW - cancer
KW - cell culture
KW - cell growth
KW - human tials
KW - lycopene
KW - oxidative damage
KW - redox sensitive molecular pathways
KW - tomato/tomato products
KW - ROS
KW - animal studies
KW - cancer
KW - cell culture
KW - cell growth
KW - human tials
KW - lycopene
KW - oxidative damage
KW - redox sensitive molecular pathways
KW - tomato/tomato products
UR - http://hdl.handle.net/10807/5568
M3 - Article
SN - 0929-8673
SP - 1846
EP - 1860
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
ER -