Role of IL-23 in the pathogenesis of psoriasis: A novel potential therapeutic target?

Andrea Chiricozzi*, Rosita Saraceno, Maria Sole Chimenti, Emma Guttman-Yassky, James G. Krueger

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Introduction: Psoriasis is a chronic inflammatory skin disorder determined by the activation of several immune cells and resident tissue cells. Various cytokines mediate inflammatory signals, including IL-23, which is an important factor involved in the differentiation of T helper (Th17) cells. Areas covered: Increasing evidence suggests that IL-23 is a central cytokine to the pathogenesis of psoriasis. An overview on both experimental and human data will be reported in order to support the hypothesis of a key pathogenic role of IL-23/Th17 axis. Expert opinion: Targeting IL-23 might be a more selective, valid and effective therapeutic approach, which, potentially, may show important advantages in terms of long-term efficacy and safety in the treatment of psoriasis. © 2014 Informa UK, Ltd.
Lingua originaleEnglish
pagine (da-a)513-525
Numero di pagine13
RivistaExpert Opinion on Therapeutic Targets
Stato di pubblicazionePubblicato - 2014


  • Anti-p19
  • Biologics
  • Guselkumab
  • IL-17
  • IL-23
  • IL-23p19
  • Psoriasis
  • Th17
  • Tildrakizumab


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