TY - JOUR
T1 - Role of Human Leukocyte Antigens at the Feto-Maternal Interface in Normal and Pathological Pregnancy: An Update.
AU - Tersigni, Chiara
AU - Meli, Federica
AU - Neri, Caterina
AU - Iacoangeli, Azzurra
AU - Franco, Rita
AU - Lanzone, Antonio
AU - Scambia, Giovanni
AU - Di Simone, Nicoletta
PY - 2020
Y1 - 2020
N2 - The successful maternal tolerance of the semi-allogeneic fetus provides an apparent immunologic paradox. Indeed, deep invasion of placental trophoblast cells into maternal uterine tissue and the following growth of the fetus have to be tolerated by a pregnant woman’s immune
system. Among the various possible protective mechanisms that may be involved in human pregnancy, the expression of a non-classical pattern of human leukocyte antigen (HLA) class I molecules and the complete lack of expression of HLA class II molecules in placental tissues seem to
be the most relevant mechanisms of fetal escape from maternal immune recognition. The importance of HLA molecules in fetal toleration by the maternal immune system is highlighted by pregnancy complications occurring in cases of abnormal HLA molecule expression at the maternal–fetal interface.
In this review, we summarize evidences about the role of placental HLA molecules in normal and pathological pregnancies.
AB - The successful maternal tolerance of the semi-allogeneic fetus provides an apparent immunologic paradox. Indeed, deep invasion of placental trophoblast cells into maternal uterine tissue and the following growth of the fetus have to be tolerated by a pregnant woman’s immune
system. Among the various possible protective mechanisms that may be involved in human pregnancy, the expression of a non-classical pattern of human leukocyte antigen (HLA) class I molecules and the complete lack of expression of HLA class II molecules in placental tissues seem to
be the most relevant mechanisms of fetal escape from maternal immune recognition. The importance of HLA molecules in fetal toleration by the maternal immune system is highlighted by pregnancy complications occurring in cases of abnormal HLA molecule expression at the maternal–fetal interface.
In this review, we summarize evidences about the role of placental HLA molecules in normal and pathological pregnancies.
KW - Human Leukocyte Antigen (HLA)
KW - maternal–fetal interface
KW - Human Leukocyte Antigen (HLA)
KW - maternal–fetal interface
UR - http://hdl.handle.net/10807/161487
U2 - 10.3390/ijms21134756
DO - 10.3390/ijms21134756
M3 - Article
SN - 1661-6596
SP - 1
EP - 13
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
ER -