Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin.

Giovanni Addolorato, Lorenzo Leggio, 33183, DI MEDICINA E CHIRURGIA "A.GEMELLI" FACOLTA', ROMA - Dipartimento di Medicina e chirurgia traslazionale, Andrea Cippitelli, Elizabeth Jerlhag, Ab Kampov Polevoy, Rm Swift

Risultato della ricerca: Contributo in rivistaArticolo in rivista

60 Citazioni (Scopus)


Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of "feeding-related" peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications.
Lingua originaleEnglish
pagine (da-a)194-202
Numero di pagine9
Stato di pubblicazionePubblicato - 2011


  • NPY
  • alcoholism
  • feeding-related pathway
  • ghrelin


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