TY - JOUR
T1 - Role of extracellular vesicles in epithelial ovarian cancer: A systematic review
AU - Lucidi, Alessandro
AU - Buca, Danilo
AU - Ronsini, Carlo
AU - Tinari, Sara
AU - Bologna, Giuseppina
AU - Buca, Davide
AU - Leombroni, Martina
AU - Liberati, Marco
AU - D’Antonio, Francesco
AU - D'Antonio, Francesco
AU - Scambia, Giovanni
AU - Lanuti, Paola
AU - Petrillo, Marco
PY - 2020
Y1 - 2020
N2 - Extracellular vesicles (EVs) are a heterogeneous group of cell-derived submicron vesicles released under physiological or pathological conditions. EVs mediate the cellular crosstalk, thus contributing to defining the tumor microenvironment, including in epithelial ovarian cancer (EOC). The available literature investigating the role of EVs in EOC has been reviewed following PRISMA guidelines, focusing on the role of EVs in early disease diagnosis, metastatic spread, and the development of chemoresistance in EOC. Data were identified from searches of Medline, Current Contents, PubMed, and from references in relevant articles from 2010 to 1 April 2020. The research yielded 194 results. Of these, a total of 36 papers, 9 reviews, and 27 original types of research were retained and analyzed. The literature findings demonstrate that a panel of EV-derived circulating miRNAs may be useful for early diagnosis of EOC. Furthermore, it appears clear that EVs are involved in mediating two crucial processes for metastatic and chemoresistance development: the epithelial–mesenchymal transition, and tumor escape from the immune system response. Further studies, more focused on in vivo evidence, are urgently needed to clarify the role of EV assessment in the clinical management of EOC patients.
AB - Extracellular vesicles (EVs) are a heterogeneous group of cell-derived submicron vesicles released under physiological or pathological conditions. EVs mediate the cellular crosstalk, thus contributing to defining the tumor microenvironment, including in epithelial ovarian cancer (EOC). The available literature investigating the role of EVs in EOC has been reviewed following PRISMA guidelines, focusing on the role of EVs in early disease diagnosis, metastatic spread, and the development of chemoresistance in EOC. Data were identified from searches of Medline, Current Contents, PubMed, and from references in relevant articles from 2010 to 1 April 2020. The research yielded 194 results. Of these, a total of 36 papers, 9 reviews, and 27 original types of research were retained and analyzed. The literature findings demonstrate that a panel of EV-derived circulating miRNAs may be useful for early diagnosis of EOC. Furthermore, it appears clear that EVs are involved in mediating two crucial processes for metastatic and chemoresistance development: the epithelial–mesenchymal transition, and tumor escape from the immune system response. Further studies, more focused on in vivo evidence, are urgently needed to clarify the role of EV assessment in the clinical management of EOC patients.
KW - Epithelial mesenchymal transition
KW - Extracellular vesicles
KW - Immunological escape
KW - MicroRNAs
KW - Ovarian cancer
KW - Tumor microenvironment
KW - Epithelial mesenchymal transition
KW - Extracellular vesicles
KW - Immunological escape
KW - MicroRNAs
KW - Ovarian cancer
KW - Tumor microenvironment
UR - http://hdl.handle.net/10807/167558
U2 - 10.3390/ijms21228762
DO - 10.3390/ijms21228762
M3 - Article
SN - 1661-6596
VL - 21
SP - 1
EP - 16
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
ER -