ROLE OF COMPLEMENT IN PREGNANCY WITH ANTIPHOSPHOLIPID SYNDROME: MECHANISMS OF PATHOGENESIS AND CLINICAL ASPECTS.

Sara De Carolis, Serafina Garofalo, Silvia Salvi, Gelsomina Del Sordo, Rossella Rella, Angela Botta, Annachiara Vitucci

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

The antiphospholipid syndrome (APS) is a disease discovered just 25 years ago. Although clinical manifestations have been clearly described, pathogenetic mechanisms are still barely understood. A recent hypothesis involves inflammation in the setting of APS morbidity and experimental data support the activation of complement cascade as a pivotal event in its physiopathology. In this review we will analyze the recent literature, focusing on contemporary and emerging aspects of complement-mediated disease pathogenesis and we will point up the clinical significance of this novel finding.
Lingua originaleEnglish
pagine (da-a)399-405
Numero di pagine7
RivistaInternational Journal of Clinical Rheumatology
Volume2013
Stato di pubblicazionePubblicato - 2013

Keywords

  • ANTIPHOSPHOLIPID SYNDROME
  • COMPLEMENT
  • PREGNANCY

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