Role of apoptosis in pressure-overload cardiomyopathy

Mario Fulvio Luigi Gaudino, Antonio Abbate, Amedeo Anselmi, A Baldi, Gw Vetrovec, R Bussani, Gian Federico Possati

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

In the natural history of pressure overload, the hypertrophy response of the left ventricle initially normalizes wall stress and allows preservation of a normal ejection fraction. Nevertheless, patients progress gradually or suddenly from compensated hypertrophy to ventricular dilation with heart failure. Long-standing hypertrophy entails a maladaptive response, which is due to derangements inherent in the myocardium rather than to a progressive increase in the cause of pressure overload. Despite this condition being linked to major clinical consequences and an unfavourable prognosis, the cellular and molecular mechanisms in pressure-overload cardiomyopathy have not yet been established. This review discusses the available experimental and clinical evidence with respect to the role played by myocardial apoptosis in pressure-overload cardiomyopathy.
Lingua originaleEnglish
pagine (da-a)227-232
Numero di pagine6
RivistaJournal of Cardiovascular Medicine
Volume9
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • Animals
  • Apoptosis
  • Cardiomyopathy, Hypertrophic
  • Disease Progression
  • Humans
  • Myocytes, Cardiac
  • Stroke Volume
  • Ventricular Pressure

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