Role of apoptosis in pressure-overload cardiomyopathy

Amedeo Anselmi, Mario Fulvio Luigi Gaudino, A Baldi, Gw Vetrovec, R Bussani, Gian Federico Possati, Antonio Abbate

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)


In the natural history of pressure overload, the hypertrophy response of the left ventricle initially normalizes wall stress and allows preservation of a normal ejection fraction. Nevertheless, patients progress gradually or suddenly from compensated hypertrophy to ventricular dilation with heart failure. Long-standing hypertrophy entails a maladaptive response, which is due to derangements inherent in the myocardium rather than to a progressive increase in the cause of pressure overload. Despite this condition being linked to major clinical consequences and an unfavourable prognosis, the cellular and molecular mechanisms in pressure-overload cardiomyopathy have not yet been established. This review discusses the available experimental and clinical evidence with respect to the role played by myocardial apoptosis in pressure-overload cardiomyopathy.
Lingua originaleEnglish
pagine (da-a)227-232
Numero di pagine6
RivistaJournal of Cardiovascular Medicine
Stato di pubblicazionePubblicato - 2008


  • Animals
  • Apoptosis
  • Cardiomyopathy, Hypertrophic
  • Disease Progression
  • Humans
  • Myocytes, Cardiac
  • Stroke Volume
  • Ventricular Pressure


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