Role of Allergic Inflammatory Cells in Coronary Artery Disease

Giampaolo Niccoli, Rocco Antonio Montone, Vito Sabato, Filippo Crea

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)


Inflammation is an important player both for the initiation and progression of coronary artery disease and for coronary plaque instability. Moreover, inflammation contributes to stent thrombosis and in-stent restenosis after percutaneous coronary intervention. In the past several decades, most studies evaluated the involvement of cellular effectors of classic inflammatory responses, such as monocytes/macrophages, neutrophils, and T cells. Yet, besides classic inflammation, mounting evidence derived from both experimental and clinical studies suggests an important, often unrecognized, role for effector cells of allergic inflammation in both the pathogenesis of coronary artery disease and adverse events following stent implantation. In this review, we discuss the role of effector cells of allergic inflammation in the setting of coronary artery disease progression and instability, and in the occurrence of adverse events following stent implantation, as well. Moreover, we discuss possible therapeutic approaches targeting different specific pathways of allergic inflammatory activation.
Lingua originaleEnglish
pagine (da-a)1736-1748
Numero di pagine13
Stato di pubblicazionePubblicato - 2018


  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • basophils
  • eosinophils
  • inflammation
  • mast cells
  • percutaneous coronary intervention
  • plaque, atherosclerotic


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