Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations

Livio Pagano*, Alessandro Busca, Anna Candoni, Chiara Cattaneo, Simone Cesaro, Rosa Fanci, Gianpaolo Nadali, Leonardo Potenza, Domenico Russo, Mario Tumbarello, Annamaria Nosari, Franco Aversa

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

56 Citazioni (Scopus)

Abstract

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and . Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, . Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates.This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy.
Lingua originaleInglese
pagine (da-a)1-13
Numero di pagine13
RivistaBlood Reviews
Volume2016
Numero di pubblicazione17
DOI
Stato di pubblicazionePubblicato - 2016

All Science Journal Classification (ASJC) codes

  • Ematologia
  • Oncologia

Keywords

  • Hematology
  • Hematopoietic stem cell transplantation
  • Leukemia
  • Molds
  • Oncology
  • Risk factors
  • Yeast

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