Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes

Stefan Hohaus, Maria Teresa Voso, S. K. Hasan, F. Buttari, T. Ottone, E. Marasco, V. Mantovani, P. Garagnani, M. A. Sanz, L. Cicconi, G. Bernardi, D. Centonze, F. Lo-Coco

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

29 Citazioni (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ).
Lingua originaleEnglish
pagine (da-a)1059-1065
Numero di pagine7
RivistaNeurology
Volume76
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Antineoplastic Agents
  • DNA Repair Enzymes
  • Genetic Predisposition to Disease
  • Humans
  • Leukemia, Promyelocytic, Acute
  • Mitoxantrone
  • Multiple Sclerosis
  • Polymorphism, Single Nucleotide
  • Risk Factors

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