Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the pancreas: a multicentre case-control study

Gabriele Capurso, Stefania Boccia, Roberto Salvia, Marco Del Chiaro, Luca Frulloni, Paolo Giorgio Arcidiacono, Alessandro Zerbi, Raffaele Manta, Carlo Fabbri, Carlo Fabbriciani, Maurizio Ventrucci, Ilaria Tarantino, Matteo Piciucchi, Antonella Carnuccio, Ugo Boggi, Emanuele Leoncini, Guido Costamagna, Gianfranco Delle Fave, Raffaele Pezzilli, Claudio BassiAlberto Leonardo Larghi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

72 Citazioni (Scopus)


OBJECTIVES: To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs). METHODS: Multicentre case–control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics. RESULTS: Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08–2.98), CP (OR: 10.10, CI 95%: 1.30–78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17–7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74–20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement. CONCLUSIONS: A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.
Lingua originaleEnglish
pagine (da-a)1003-1009
Numero di pagine7
Stato di pubblicazionePubblicato - 2013


  • Adenocarcinoma, Mucinous
  • Adenocarcinoma, Papillary
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking
  • Carcinoma, Pancreatic Ductal
  • Case-Control Studies
  • Diabetes Mellitus
  • Female
  • Humans
  • Indole Alkaloids
  • Insulin
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Pancreatic Neoplasms
  • Pancreatitis, Chronic
  • Peptic Ulcer
  • Questionnaires
  • Risk Factors
  • Smoking


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