Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Tatiana Natasha Toporcov; Ariana Znaor; Zuo-Feng Zhang; Guo-Pei Yu; Deborah M. Winn; Qingyi Wei; Marta Vilensky; Thomas Vaughan; Peter Thomson; Renato Talamini; Neonila Szeszenia-Dabrowska; Erich M. Sturgis; Elaine Smith; Oxana Shangina; Stephen M. Schwartz; Stimson Schantz; Peter Rudnai; Lorenzo Richiardi; Heribert Ramroth; Mark P. Purdue; Andrew F. Olshan; José Eluf-Neto; Joshua Muscat; Raquel Ajub Moyses; Hal Morgenstern; Ana Menezes; Michael Mcclean; Keitaro Matsuo; Dana Mates; Tatiana V. Macfarlane; Jolanta Lissowska; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Pagona Lagiou; Sergio Koifman; Kristina Kjaerheim; Karl Kelsey; Ivana Holcatova; Rolando Herrero; Claire Healy; Richard B. Hayes; Silvia Franceschi; Leticia Fernandez; Eleonora Fabianova; Alexander W. Daudt; Otávio Alberto Curioni; Luigino Dal Maso; Maria Paula Curado; David I. Conway; Chu Chen; Xavier Castellsague; Gabriella Cadoni; Cristina Canova; Paul Brennan; Stefania Boccia; José Leopoldo Ferreira Antunes; Wolfgang Ahrens; Antonio Agudo; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Victor Wünsch Filho

doi:10.1093/ije/dyu255

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Tatiana Natasha Toporcov, Ariana Znaor, Zuo-Feng Zhang, Guo-Pei Yu, Deborah M. Winn, Qingyi Wei, Marta Vilensky, Thomas Vaughan, Peter Thomson, Renato Talamini, Neonila Szeszenia-Dabrowska, Erich M. Sturgis, Elaine Smith, Oxana Shangina, Stephen M. Schwartz, Stimson Schantz, Peter Rudnai, Lorenzo Richiardi, Heribert Ramroth, Mark P. PurdueAndrew F. Olshan, José Eluf-Neto, Joshua Muscat, Raquel Ajub Moyses, Hal Morgenstern, Ana Menezes, Michael Mcclean, Keitaro Matsuo, Dana Mates, Tatiana V. Macfarlane, Jolanta Lissowska, Fabio Levi, Philip Lazarus, Carlo La Vecchia, Pagona Lagiou, Sergio Koifman, Kristina Kjaerheim, Karl Kelsey, Ivana Holcatova, Rolando Herrero, Claire Healy, Richard B. Hayes, Silvia Franceschi, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Otávio Alberto Curioni, Luigino Dal Maso, Maria Paula Curado, David I. Conway, Chu Chen, Xavier Castellsague, Gabriella Cadoni, Cristina Canova, Paul Brennan, Stefania Boccia, José Leopoldo Ferreira Antunes, Wolfgang Ahrens, Antonio Agudo, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Victor Wünsch Filho

Risultato della ricerca: Contributo in rivista › Articolo in rivista

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Abstract

Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. METHODS: We pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults. CONCLUSIONS: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Lingua originale	English
pagine (da-a)	169-185
Numero di pagine	17
Rivista	International Journal of Epidemiology
DOI	https://doi.org/10.1093/ije/dyu255
Stato di pubblicazione	Pubblicato - 2015

Keywords

head and neck cancer
prognostic factors

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Toporcov, T. N., Znaor, A., Zhang, Z-F., Yu, G-P., Winn, D. M., Wei, Q., Vilensky, M., Vaughan, T., Thomson, P., Talamini, R., Szeszenia-Dabrowska, N., Sturgis, E. M., Smith, E., Shangina, O., Schwartz, S. M., Schantz, S., Rudnai, P., Richiardi, L., Ramroth, H., ... Filho, V. W. (2015). Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. International Journal of Epidemiology, 169-185. https://doi.org/10.1093/ije/dyu255

@article{d7cf77a5cf2c497e9b6587b9d8aec740,

title = "Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium",

abstract = "Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. METHODS: We pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults. CONCLUSIONS: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.",

keywords = "head and neck cancer, prognostic factors, head and neck cancer, prognostic factors",

author = "Toporcov, {Tatiana Natasha} and Ariana Znaor and Zuo-Feng Zhang and Guo-Pei Yu and Winn, {Deborah M.} and Qingyi Wei and Marta Vilensky and Thomas Vaughan and Peter Thomson and Renato Talamini and Neonila Szeszenia-Dabrowska and Sturgis, {Erich M.} and Elaine Smith and Oxana Shangina and Schwartz, {Stephen M.} and Stimson Schantz and Peter Rudnai and Lorenzo Richiardi and Heribert Ramroth and Purdue, {Mark P.} and Olshan, {Andrew F.} and Jos{\'e} Eluf-Neto and Joshua Muscat and Moyses, {Raquel Ajub} and Hal Morgenstern and Ana Menezes and Michael Mcclean and Keitaro Matsuo and Dana Mates and Macfarlane, {Tatiana V.} and Jolanta Lissowska and Fabio Levi and Philip Lazarus and Vecchia, {Carlo La} and Pagona Lagiou and Sergio Koifman and Kristina Kjaerheim and Karl Kelsey and Ivana Holcatova and Rolando Herrero and Claire Healy and Hayes, {Richard B.} and Silvia Franceschi and Leticia Fernandez and Eleonora Fabianova and Daudt, {Alexander W.} and Curioni, {Ot{\'a}vio Alberto} and Maso, {Luigino Dal} and Curado, {Maria Paula} and Conway, {David I.} and Chu Chen and Xavier Castellsague and Gabriella Cadoni and Cristina Canova and Paul Brennan and Stefania Boccia and Antunes, {Jos{\'e} Leopoldo Ferreira} and Wolfgang Ahrens and Antonio Agudo and Paolo Boffetta and Mia Hashibe and Lee, {Yuan-Chin Amy} and Filho, {Victor W{\"u}nsch}",

year = "2015",

doi = "10.1093/ije/dyu255",

language = "English",

pages = "169--185",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485",

}

Toporcov, TN, Znaor, A, Zhang, Z-F, Yu, G-P, Winn, DM, Wei, Q, Vilensky, M, Vaughan, T, Thomson, P, Talamini, R, Szeszenia-Dabrowska, N, Sturgis, EM, Smith, E, Shangina, O, Schwartz, SM, Schantz, S, Rudnai, P, Richiardi, L, Ramroth, H, Purdue, MP, Olshan, AF, Eluf-Neto, J, Muscat, J, Moyses, RA, Morgenstern, H, Menezes, A, Mcclean, M, Matsuo, K, Mates, D, Macfarlane, TV, Lissowska, J, Levi, F, Lazarus, P, Vecchia, CL, Lagiou, P, Koifman, S, Kjaerheim, K, Kelsey, K, Holcatova, I, Herrero, R, Healy, C, Hayes, RB, Franceschi, S, Fernandez, L, Fabianova, E, Daudt, AW, Curioni, OA, Maso, LD, Curado, MP, Conway, DI, Chen, C, Castellsague, X, Cadoni, G, Canova, C, Brennan, P, Boccia, S, Antunes, JLF, Ahrens, W, Agudo, A, Boffetta, P, Hashibe, M, Lee, Y-CA & Filho, VW 2015, 'Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium', International Journal of Epidemiology, pagg. 169-185. https://doi.org/10.1093/ije/dyu255

TY - JOUR

T1 - Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

AU - Toporcov, Tatiana Natasha

AU - Znaor, Ariana

AU - Zhang, Zuo-Feng

AU - Yu, Guo-Pei

AU - Winn, Deborah M.

AU - Wei, Qingyi

AU - Vilensky, Marta

AU - Vaughan, Thomas

AU - Thomson, Peter

AU - Talamini, Renato

AU - Szeszenia-Dabrowska, Neonila

AU - Sturgis, Erich M.

AU - Smith, Elaine

AU - Shangina, Oxana

AU - Schwartz, Stephen M.

AU - Schantz, Stimson

AU - Rudnai, Peter

AU - Richiardi, Lorenzo

AU - Ramroth, Heribert

AU - Purdue, Mark P.

AU - Olshan, Andrew F.

AU - Eluf-Neto, José

AU - Muscat, Joshua

AU - Moyses, Raquel Ajub

AU - Morgenstern, Hal

AU - Menezes, Ana

AU - Mcclean, Michael

AU - Matsuo, Keitaro

AU - Mates, Dana

AU - Macfarlane, Tatiana V.

AU - Lissowska, Jolanta

AU - Levi, Fabio

AU - Lazarus, Philip

AU - Vecchia, Carlo La

AU - Lagiou, Pagona

AU - Koifman, Sergio

AU - Kjaerheim, Kristina

AU - Kelsey, Karl

AU - Holcatova, Ivana

AU - Herrero, Rolando

AU - Healy, Claire

AU - Hayes, Richard B.

AU - Franceschi, Silvia

AU - Fernandez, Leticia

AU - Fabianova, Eleonora

AU - Daudt, Alexander W.

AU - Curioni, Otávio Alberto

AU - Maso, Luigino Dal

AU - Curado, Maria Paula

AU - Conway, David I.

AU - Chen, Chu

AU - Castellsague, Xavier

AU - Cadoni, Gabriella

AU - Canova, Cristina

AU - Brennan, Paul

AU - Boccia, Stefania

AU - Antunes, José Leopoldo Ferreira

AU - Ahrens, Wolfgang

AU - Agudo, Antonio

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Lee, Yuan-Chin Amy

AU - Filho, Victor Wünsch

PY - 2015

Y1 - 2015

N2 - Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. METHODS: We pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults. CONCLUSIONS: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

AB - Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. METHODS: We pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults. CONCLUSIONS: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

KW - head and neck cancer

KW - prognostic factors

KW - head and neck cancer

KW - prognostic factors

UR - http://hdl.handle.net/10807/66116

U2 - 10.1093/ije/dyu255

DO - 10.1093/ije/dyu255

M3 - Article

SN - 0300-5771

SP - 169

EP - 185

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

ER -

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

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