Risk factors for abnormally invasive placenta: a systematic review and meta-analysis

Antonia Iacovelli, Marco Liberati, Asma Khalil, Ilan Timor-Trisch, Martina Leombroni, Danilo Buca, Michela Milani, Maria Elena Flacco, Lamberto Manzoli, Francesco Fanfani, Giuseppe Calì, Alessandra Familiari, Giovanni Scambia, Francesco D’Antonio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (SciVal)


Purpose of the article. To explore the strength of association between different maternal and pregnancy characteristics and the occurrence of abnormally invasive placenta (AIP). Materials and methods: Pubmed, Embase, CINAHL databases were searched. The risk factors for AIP explored were: obesity, age >35 years, smoking before or during pregnancy, placenta previa, prior cesarean section (CS), placenta previa and prior CS, prior uterine surgery, abortion and uterine curettage, in vitro fertilization (IVF) pregnancy and interval between a previous CS, and a subsequent pregnancy. Random-effect head-to-head meta-analyses were used to analyze the data. Results: Forty-six were included in the systematic review. Maternal obesity (Odd ratio, OR: 1.4, 95% CI 1.0–1.8), advanced maternal age (OR: 3.1, 95% CI 1.4–7.0) and parity (OR: 2.5, 95% CI 1.7–3.6), but not smoking were associated with a higher risk of AIP. The presence of placenta previa in women with at least a prior CS was associated with a higher risk of AIP compared to controls, with an OR of 12.0, 95% CI 1.6–88.0. Furthermore, the risk of AIP increased with the number of prior CS (OR of 2.6, 95% CI 1.6–4.4 and 5.4, 95% CI 1.7–17.4 for two and three prior CS respectively). Finally, IVF pregnancies were associated with a high risk of AIP, with an OR of 2.8 (95% CI 1.2–6.8). Conclusion: A prior CS and placenta previa are among the strongest risk factors for the occurrence of AIP.
Lingua originaleEnglish
pagine (da-a)471-481
Numero di pagine11
Stato di pubblicazionePubblicato - 2020


  • Abnormally invasive placenta
  • cesarean section
  • placenta
  • risk factors
  • systematic review and meta-analysis


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