Risk Factors and prognostic indicators of bacterial meningitis in a cohort of 3580 postneurosurgical patients

Mario Tumbarello, Teresa Spanu, Evelina Tacconelli, G Federico, R Roselli, M Iacoangeli, M Scerrati

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

51 Citazioni (Scopus)

Abstract

In order to identify the incidence, risk factors and prognostic indicators of postneurosurgical bacterial meningitis, a 9-y retrospective cohort study was performed. The cohort comprised 3580 individuals who underwent neurosurgical operations at the Department of Neurosurgery of Catholic University, Rome, a 1,700-bed university hospital. We observed 52 episodes of postneurosurgical meningitis, with infection rates of 1.4/100 patients, 0.8/100 operations for craniotomies and 2.6/100 operations for internal cerebrospinal fluid (CSF) shunt or ventriculostomy with external drainage. The overall infection rate decreased from 2.5/100 operations in 1989 to 0.9/100 in 1997 (p = 0.03). Logistic regression analysis indicated that duration of ventriculostomy with external drainage [p < 0.01; odds ratio (OR) = 9.67; 95% confidence interval (CI) = 2.44-38.321 and increasing value of the APACHE III score (p <0.01; OR = 8.51; 95% CI = 2.15-33.68) were independent risk factors for development of meningitis. The overall case fatality rate was 8%. Predictors of mortality were low ( < 1.66 mmol/l) CSF glucose concentration (p = 0.001), increasing value of the APACHE IIl score (p = 0.002) and Gram-negative aetiology (p = 0.003).
Lingua originaleEnglish
pagine (da-a)533-537
Numero di pagine5
RivistaSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
Stato di pubblicazionePubblicato - 2001

Keywords

  • meningitis
  • neurosurgery
  • nosocomial infections

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