Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection

A. Russo; M. Falcone; Massimo Fantoni; Rita Murri; Luca Masucci; P. Carfagna; M. C. Ghezzi; Brunella Posteraro; Maurizio Sanguinetti; M. Venditti

doi:10.1016/j.cmi.2014.12.024

Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection

A. Russo, M. Falcone, Massimo Fantoni, Rita Murri, Luca Masucci, P. Carfagna, M. C. Ghezzi, Brunella Posteraro, Maurizio Sanguinetti, M. Venditti

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

22 Citazioni (Scopus)

Abstract

The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.

Lingua originale	English
pagine (da-a)	493.e1-493.e1-4
Numero di pagine	4
Rivista	Clinical Microbiology and Infection
Volume	21
DOI	https://doi.org/10.1016/j.cmi.2014.12.024
Stato di pubblicazione	Pubblicato - 2015

Keywords

Candida bloodstream infection
Candida colonization
Clostridium difficile infection
oral vancomycin
ribotype 027

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10.1016/j.cmi.2014.12.024

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title = "Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection",

abstract = "The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.",

keywords = "Candida bloodstream infection, Candida colonization, Clostridium difficile infection, oral vancomycin, ribotype 027, Candida bloodstream infection, Candida colonization, Clostridium difficile infection, oral vancomycin, ribotype 027",

author = "A. Russo and M. Falcone and Massimo Fantoni and Rita Murri and Luca Masucci and P. Carfagna and Ghezzi, {M. C.} and Brunella Posteraro and Maurizio Sanguinetti and M. Venditti",

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language = "English",

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TY - JOUR

T1 - Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection

AU - Russo, A.

AU - Falcone, M.

AU - Fantoni, Massimo

AU - Murri, Rita

AU - Masucci, Luca

AU - Carfagna, P.

AU - Ghezzi, M. C.

AU - Posteraro, Brunella

AU - Sanguinetti, Maurizio

AU - Venditti, M.

PY - 2015

Y1 - 2015

N2 - The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.

AB - The alterations occurring in the intestinal flora during Clostridium difficile infection (CDI) may promote the translocation of Candida to the blood and the development of candidaemia. The aim of our study was to analyse clinical findings of these patients to determine the risk factors associated with the development of candidaemia subsequent to CDI. We compared 35 patients with candidaemia subsequent to CDI with 105 patients with CDI. Patients with candidaemia showed more severe infections and higher mortality. The ribotype 027 strain and vancomycin treatment at ≥1000 mg/day were prevalent in patients developing candidaemia. CDI may predispose to the translocation of Candida.

KW - Candida bloodstream infection

KW - Candida colonization

KW - Clostridium difficile infection

KW - oral vancomycin

KW - ribotype 027

KW - Candida bloodstream infection

KW - Candida colonization

KW - Clostridium difficile infection

KW - oral vancomycin

KW - ribotype 027

UR - http://hdl.handle.net/10807/69052

U2 - 10.1016/j.cmi.2014.12.024

DO - 10.1016/j.cmi.2014.12.024

M3 - Article

SN - 1198-743X

VL - 21

SP - 493.e1-493.e1-4

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

ER -

Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection

Abstract

Keywords

Accesso al documento

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