Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: In vivo confocal microscopy investigation

Aldo Caporossi, Cosimo Mazzotta, Claudio Traversi, Elisabetta Nuti, Maria Caterina Sparano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

PURPOSE. To establish the real localization of rifabutin-related corneal deposits in a patient with human immunodeficiency virus (HIV) infection by in vivo HRT II confocal microscopy with related clinicopathologic implications. METHODS. Observational case report. After Siena University Institutional Review Board approval in May 2008 and specific informed consent, a 54-year-old patient with HIV infection under rifabutin treatment for acquired immunodeficiency syndrome-related Mycobacterium avium complex prevention who developed diffuse corneal deposits was examined at the Department of Ophthalmology of Siena University. He underwent a complete clinical eye examination, biomicroscopy, and digital slit lamp photographs, endothelial specular microscopy, ultrasound pachymetry, and confocal microscopy by HRT II system. RESULTS. Confocal scans revealed the presence of deep stromal and pre descemetic hyperreflective polymorphous deposits. In vivo confocal examination excluded the presence of rifabutin-related deposits at endothelial level. CONCLUSIONS. Confocal microscopy enables establishment of the real localization of rifabutin deposits at deep stromal level, providing a better qualitative analysis of all corneal layers compared to biomicroscopic examination, with clinical and physiopathologic implications. © Wichtig Editore, 2009.
Lingua originaleEnglish
pagine (da-a)481-483
Numero di pagine3
RivistaEuropean Journal of Ophthalmology
Volume19
Stato di pubblicazionePubblicato - 2009

Keywords

  • Confocal microscopy
  • Corneal deposits
  • HIV infection
  • Ophthalmology
  • Rifabutin

Fingerprint Entra nei temi di ricerca di 'Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: In vivo confocal microscopy investigation'. Insieme formano una fingerprint unica.

Cita questo