Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.

Hans F. A. Vasen; Ignacio Blanco; Katja Aktan-Collan; Jessica P. Gopie; Angel Alonso; Stefan Aretz; Inge Bernstein; Lucio Bertario; John Burn; Gabriel Capella; Chrystelle Colas; Christoph Engel; Ian M. Frayling; Karl Heinimann Maurizio Genuardi; Maurizio Genuardi; Frederik J. Hes; Shirley V. Hodgson; John A. Karagiannis; Fiona Lalloo; Annika Lindblom; Jukka-Pekka Mecklin; Pal Møller; Torben Myrhoj; Fokko M. Nagengast; Yann Parc; Maurizio Ponz De Leon; Laura Renkonen-Sinisalo; Julian R. Sampson; Astrid Stormorken; Rolf H. Sijmons; Sabine Tejpar; Huw J. W. Thomas; Nils Rahner; Juul T. Wijnen; Heikki Juhani Järvinen; Gabriela Möslein

doi:10.1136/gutjnl-2012-304356

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.

Hans F. A. Vasen, Ignacio Blanco, Katja Aktan-Collan, Jessica P. Gopie, Angel Alonso, Stefan Aretz, Inge Bernstein, Lucio Bertario, John Burn, Gabriel Capella, Chrystelle Colas, Christoph Engel, Ian M. Frayling, Karl Heinimann Maurizio Genuardi, Maurizio Genuardi, Frederik J. Hes, Shirley V. Hodgson, John A. Karagiannis, Fiona Lalloo, Annika LindblomJukka-Pekka Mecklin, Pal Møller, Torben Myrhoj, Fokko M. Nagengast, Yann Parc, Maurizio Ponz De Leon, Laura Renkonen-Sinisalo, Julian R. Sampson, Astrid Stormorken, Rolf H. Sijmons, Sabine Tejpar, Huw J. W. Thomas, Nils Rahner, Juul T. Wijnen, Heikki Juhani Järvinen, Gabriela Möslein

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families

Lingua originale	English
pagine (da-a)	812-823
Numero di pagine	12
Rivista	Gut
Volume	62
DOI	https://doi.org/10.1136/gutjnl-2012-304356
Stato di pubblicazione	Pubblicato - 2013

Keywords

cancer

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Vasen, H. F. A., Blanco, I., Aktan-Collan, K., Gopie, J. P., Alonso, A., Aretz, S., Bernstein, I., Bertario, L., Burn, J., Capella, G., Colas, C., Engel, C., Frayling, I. M., Maurizio Genuardi, K. H., Genuardi, M., Hes, F. J., Hodgson, S. V., Karagiannis, J. A., Lalloo, F., ... Möslein, G. (2013). Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut, 62, 812-823. https://doi.org/10.1136/gutjnl-2012-304356

@article{1cf4e2ebd2e84a48aa6a94293bf54bae,

title = "Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.",

abstract = "Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families",

keywords = "cancer, cancer",

author = "Vasen, {Hans F. A.} and Ignacio Blanco and Katja Aktan-Collan and Gopie, {Jessica P.} and Angel Alonso and Stefan Aretz and Inge Bernstein and Lucio Bertario and John Burn and Gabriel Capella and Chrystelle Colas and Christoph Engel and Frayling, {Ian M.} and {Maurizio Genuardi}, {Karl Heinimann} and Maurizio Genuardi and Hes, {Frederik J.} and Hodgson, {Shirley V.} and Karagiannis, {John A.} and Fiona Lalloo and Annika Lindblom and Jukka-Pekka Mecklin and Pal M{\o}ller and Torben Myrhoj and Nagengast, {Fokko M.} and Yann Parc and {De Leon}, {Maurizio Ponz} and Laura Renkonen-Sinisalo and Sampson, {Julian R.} and Astrid Stormorken and Sijmons, {Rolf H.} and Sabine Tejpar and Thomas, {Huw J. W.} and Nils Rahner and Wijnen, {Juul T.} and J{\"a}rvinen, {Heikki Juhani} and Gabriela M{\"o}slein",

year = "2013",

doi = "10.1136/gutjnl-2012-304356",

language = "English",

volume = "62",

pages = "812--823",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ / British Medical Journal Publishing Group:PO Box 299, London WC1H 9TD United Kingdom:011 44 20 73836270, EMAIL: [email protected], INTERNET: http://www.bmjpg.com/bmj, Fax: 011 44 20 73836402",

}

Vasen, HFA, Blanco, I, Aktan-Collan, K, Gopie, JP, Alonso, A, Aretz, S, Bernstein, I, Bertario, L, Burn, J, Capella, G, Colas, C, Engel, C, Frayling, IM, Maurizio Genuardi, KH, Genuardi, M, Hes, FJ, Hodgson, SV, Karagiannis, JA, Lalloo, F, Lindblom, A, Mecklin, J-P, Møller, P, Myrhoj, T, Nagengast, FM, Parc, Y, De Leon, MP, Renkonen-Sinisalo, L, Sampson, JR, Stormorken, A, Sijmons, RH, Tejpar, S, Thomas, HJW, Rahner, N, Wijnen, JT, Järvinen, HJ & Möslein, G 2013, 'Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.', Gut, vol. 62, pagg. 812-823. https://doi.org/10.1136/gutjnl-2012-304356

TY - JOUR

T1 - Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.

AU - Vasen, Hans F. A.

AU - Blanco, Ignacio

AU - Aktan-Collan, Katja

AU - Gopie, Jessica P.

AU - Alonso, Angel

AU - Aretz, Stefan

AU - Bernstein, Inge

AU - Bertario, Lucio

AU - Burn, John

AU - Capella, Gabriel

AU - Colas, Chrystelle

AU - Engel, Christoph

AU - Frayling, Ian M.

AU - Maurizio Genuardi, Karl Heinimann

AU - Genuardi, Maurizio

AU - Hes, Frederik J.

AU - Hodgson, Shirley V.

AU - Karagiannis, John A.

AU - Lalloo, Fiona

AU - Lindblom, Annika

AU - Mecklin, Jukka-Pekka

AU - Møller, Pal

AU - Myrhoj, Torben

AU - Nagengast, Fokko M.

AU - Parc, Yann

AU - De Leon, Maurizio Ponz

AU - Renkonen-Sinisalo, Laura

AU - Sampson, Julian R.

AU - Stormorken, Astrid

AU - Sijmons, Rolf H.

AU - Tejpar, Sabine

AU - Thomas, Huw J. W.

AU - Rahner, Nils

AU - Wijnen, Juul T.

AU - Järvinen, Heikki Juhani

AU - Möslein, Gabriela

PY - 2013

Y1 - 2013

N2 - Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families

AB - Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families

KW - cancer

UR - http://hdl.handle.net/10807/148724

U2 - 10.1136/gutjnl-2012-304356

DO - 10.1136/gutjnl-2012-304356

M3 - Article

SN - 0017-5749

VL - 62

SP - 812

EP - 823

JO - Gut

JF - Gut

ER -

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.

Abstract

Keywords

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