Review article: breath testing for human liver function assessment.

Alessandro Armuzzi, Maria Assunta Zocco, Luca Miele, Antonio Grieco, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Marcello Candelli, Enrico Celestino Nista, Filippo Cremonini, Immacolata Alessia Cazzato, A Andreoli, A De Lorenzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

109 Citazioni (Scopus)

Abstract

Carbon-labelled breath tests were proposed as tools for the evaluation of human liver function 30 years ago, but have never become part of clinical routine. One reason for this is the complex role of the liver in metabolic regulation, making it difficult to provide essential information for the management of patients with liver disease with a single test and to satisfy the hepatology community. As a result, a battery of breath tests have been developed. Depending on the test compound administered, different metabolic pathways (microsomal, cytosolic, mitochondrial) can be examined. Most available data come from microsomal function tests, whilst information about cytosolic and mitochondrial liver function is more limited. However, breath tests have shown promise in some studies, in particular to predict the outcome of patients with chronic liver disease or to monitor hepatic function after treatment. Whilst we await new substrates that can be used to measure liver function in a more valid manner, and large prospective studies to assess the usefulness of available test compounds, the aim of this review is to describe how far we have come in this controversial and unresolved issue
Lingua originaleEnglish
pagine (da-a)1977-1996
Numero di pagine20
RivistaALIMENTARY PHARMACOLOGY & THERAPEUTICS
Stato di pubblicazionePubblicato - 2002

Keywords

  • breath test
  • liver function

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