Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Correlation with Macular Function

Benedetto Falsini, Angelo Maria Minnella, Stanislao Rizzo, Maria Cristina Savastano, Alfonso Savastano, Gloria Gambini, Giorgio Placidi, Marco Piccardi, Grazia M Cozzupoli, Umberto De Vico

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in patients with non-exudative age-related macular degeneration (neAMD). In this retrospective study, 29 eyes of 29 patients affected by early (24.14%), intermediate (41.38%), and advanced (34.48%) neAMD were evaluated. All enrolled eyes were studied with OCT to measure the total area of SRI, by using an automated standardized algorithm. Visual acuity and fERG were assessed. The area of SRI was negatively correlated with fERG amplitude (r <= -0.4, p <= 0.02) and best-corrected visual acuity (BCVA) (r <= 0.4, p <= 0.04). Our results indicate that the severity of retinal pigment epithelium and outer retina atrophy (RORA), indirectly quantified through the detection of SRI areas by commercial OCT algorithms, is correlated with central retinal dysfunction, as determined by visual acuity and fERG, supporting the combined use of structural exams and functional tests as valid tools to detect the extent of RPE and photoreceptors' disruption.
Lingua originaleEnglish
pagine (da-a)2973-N/A
Numero di pagine10
RivistaJournal of Clinical Medicine
Volume9
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • age-related macular degeneration
  • sub-RPE illumination
  • outer retina and retinal pigment epithelium atrophy
  • focal electroretinogram

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