Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance

Caterina Conte, Luigi Fontana, J Yoshino, B Mittendorfer, S Imai, Kb Schechtman, C Gu, I Kunz, F Rossi Fanelli, Bw Patterson, S. Klein

Risultato della ricerca: Contributo in rivistaArticolo in rivista

270 Citazioni (Scopus)

Abstract

Resveratrol has been reported to improve metabolic function in metabolically abnormal rodents and humans, but it has not been studied in nonobese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in nonobese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation increased plasma resveratrol concentration, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, SIRT1, NAMPT, and PPARGC1A, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance.
Lingua originaleEnglish
pagine (da-a)658-664
Numero di pagine7
RivistaCell Metabolism
Volume16
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adipose Tissue
  • Antioxidants
  • Body Composition
  • Dietary Supplements
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Gene Expression Regulation
  • Glucose Clamp Technique
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Liver
  • Middle Aged
  • Muscle, Skeletal
  • Placebo Effect
  • Stilbenes

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