Restless legs syndrome: A new comorbidity in idiopathic pulmonary fibrosis

Francesco Varone, Ludovica Friello, Chiara Di Blasi, Giacomo Sgalla, Marco Luigetti, Bruno Iovene, Luca Richeldi, Giacomo Della Marca, Valerio Brunetti

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Objective: Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical features of RLS in a cohort of IPF patients. Methods: Fifty patients with diagnosis of IPF were prospectively enrolled. RLS was diagnosed using the validated 5-item RLS criteria. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. The prevalence of RLS in the IPF group was compared to that observed in a group of 293 patients referred for suspect of sleep disorders. The relationships between RLS and clinical parameters were determined using multivariate logistic regression. Results: Prevalence of RLS in the IPF group was significantly higher than in the control population of patients referred for sleep disorders (IPF: 24%, controls 10%: χ2 6.49, p = 0.011). Higher PSQI score confirmed to be associated with RLS after adjusting for demographics and clinical parameters of disease severity (OR = 1.38, 95%CI 1.08–1.76; p = 0.01). Conclusions: RLS is highly prevalent in IPF and significantly worsen sleep quality in these patients. The benefit/risk ratio of a specific therapeutic intervention for RLS in IPF should be assessed in further prospective research.
Lingua originaleEnglish
pagine (da-a)105982-105982
Numero di pagine1
RivistaRespiratory Medicine
Stato di pubblicazionePubblicato - 2020


  • Idiopathic pulmonary fibrosis
  • Interstitial lung disease
  • Restless legs syndrome
  • Sleep quality
  • Sleep-related movements disorders


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