TY - JOUR
T1 - Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with Alzheimer's disease: an Italian multicenter study
AU - Babiloni, C
AU - Lizio, R
AU - Carducci, F
AU - Vecchio, Fabio Maria
AU - Redolfi, A
AU - Marino, S
AU - Tedeschi, G
AU - Montella, P
AU - Guizzaro, A
AU - Esposito, F
AU - Bozzao, A
AU - Giubilei, F
AU - Orzi, F
AU - Quattrocchi, Cc
AU - Soricelli, A
AU - Salvatore, Enrico
AU - Baglieri, A
AU - Bramanti, P
AU - Cavedo, E
AU - Ferri, R
AU - Cosentino, F
AU - Ferrara, Maria
AU - Mundi, C
AU - Grilli, G
AU - Pugliese, S
AU - Gerardi, G
AU - Parisi, L
AU - Vernieri, F
AU - Triggiani, Ai
AU - Pedersen, Jt
AU - Hårdemark, H
AU - Rossini, Paolo Maria
AU - Frisoni, Gb
PY - 2011
Y1 - 2011
N2 - Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI- (people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI- group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD- group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD- group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.
AB - Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI- (people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI- group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD- group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD- group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.
KW - Aged
KW - Alzheimer Disease
KW - Cerebral Cortex
KW - Electroencephalography
KW - Female
KW - Humans
KW - Italy
KW - Magnetic Resonance Imaging
KW - Male
KW - Mild Cognitive Impairment
KW - Nerve Fibers, Myelinated
KW - Neuropsychological Tests
KW - Aged
KW - Alzheimer Disease
KW - Cerebral Cortex
KW - Electroencephalography
KW - Female
KW - Humans
KW - Italy
KW - Magnetic Resonance Imaging
KW - Male
KW - Mild Cognitive Impairment
KW - Nerve Fibers, Myelinated
KW - Neuropsychological Tests
UR - http://hdl.handle.net/10807/10913
U2 - 10.3233/JAD-2011-101710
DO - 10.3233/JAD-2011-101710
M3 - Article
SN - 1387-2877
VL - 26
SP - 331
EP - 346
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
ER -