Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with Alzheimer's disease: an Italian multicenter study

Fabio Maria Vecchio, Paolo Maria Rossini, C Babiloni, R Lizio, F Carducci, A Redolfi, S Marino, G Tedeschi, P Montella, A Guizzaro, F Esposito, A Bozzao, F Giubilei, F Orzi, Cc Quattrocchi, A Soricelli, Enrico Salvatore, A Baglieri, P Bramanti, E CavedoR Ferri, F Cosentino, Maria Ferrara, C Mundi, G Grilli, S Pugliese, G Gerardi, L Parisi, F Vernieri, Ai Triggiani, Jt Pedersen, H Hårdemark, Gb Frisoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)

Abstract

Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI- (people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI- group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD- group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD- group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.
Lingua originaleEnglish
pagine (da-a)331-346
Numero di pagine16
RivistaJournal of Alzheimer's Disease
Volume26
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Alzheimer Disease
  • Cerebral Cortex
  • Electroencephalography
  • Female
  • Humans
  • Italy
  • Magnetic Resonance Imaging
  • Male
  • Mild Cognitive Impairment
  • Nerve Fibers, Myelinated
  • Neuropsychological Tests

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