TY - JOUR
T1 - Resolution of immune haemolytic anaemia with allogeneic bone marrow transplantation after an unsuccessful autograft
AU - De Stefano, Piero
AU - De Stefano, Pietro
AU - Zecca, Marco
AU - Giorgiani, Giovanna
AU - Perotti, Cesare
AU - Giraldi, Eugenia
AU - Locatelli, Franco
PY - 1999
Y1 - 1999
N2 - Autologous transplantation of lymphocyte-depleted peripheral blood stem cells (PBSC) has been proposed for treatment of patients with severe autoimmune disease. However, several patients have been reported to achieve only transient remissions. We report on a child with thalassaemia intermedia and immune-mediated haemolytic anaemia, given an autologous lymphocyte-depleted PBSC transplant, who relapsed 7 weeks after transplant. A complete remission, lasting 18 months to date, was obtained with allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor. This experience indicates that, in selected cases, allogeneic BMT may be the treatment of choice for life-threatening autoimmune disease. A graft-versus-autoimmunity effect may favour the eradication of the recipient autoaggressive lymphocytes.
AB - Autologous transplantation of lymphocyte-depleted peripheral blood stem cells (PBSC) has been proposed for treatment of patients with severe autoimmune disease. However, several patients have been reported to achieve only transient remissions. We report on a child with thalassaemia intermedia and immune-mediated haemolytic anaemia, given an autologous lymphocyte-depleted PBSC transplant, who relapsed 7 weeks after transplant. A complete remission, lasting 18 months to date, was obtained with allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor. This experience indicates that, in selected cases, allogeneic BMT may be the treatment of choice for life-threatening autoimmune disease. A graft-versus-autoimmunity effect may favour the eradication of the recipient autoaggressive lymphocytes.
KW - autoimmune disease
KW - thalassaemia
KW - immunosuppressive treatment
KW - bone marrow transplantation
KW - immune haemolytic anaemia
KW - autoimmune disease
KW - thalassaemia
KW - immunosuppressive treatment
KW - bone marrow transplantation
KW - immune haemolytic anaemia
UR - http://hdl.handle.net/10807/263698
U2 - 10.1046/j.1365-2141.1999.01658.x
DO - 10.1046/j.1365-2141.1999.01658.x
M3 - Article
SN - 0007-1048
VL - 106
SP - 1063
EP - 1064
JO - British Journal of Haematology
JF - British Journal of Haematology
ER -