Residual respiratory impairment after COVID-19 pneumonia

Luca Richeldi, Francesco Landi, Elisa Gremese, Roberto Bernabei, Massimo Fantoni, Antonio Gasbarrini, Emanuele Marzetti, Enrica Tamburrini, Rita Murri, Antonella Cingolani, Giulio Ventura, Giovanni Addolorato, Francesco Franceschi, Maria Assunta Zocco, Stanislao Rizzo, Maria Cristina Savastano, Giulio Cesare Passali, Gaetano Paludetti, Jacopo Galli, Piero ValentiniLuca Richeldi, Gabriele Sani, Luigi Natale, Anna Rita Larici, Riccardo Marano, Angelo Santoliquido, Francesco Lombardi, Bruno Iovene, Chiara Pierandrei, Marialessia Lerede, Francesco Varone, Carlo Romano Settanni, Francesca Benvenuto, Giulia Bramato, Angelo Carfi', Francesca Ciciarello, Maria Rita Lo Monaco, Anna Maria Martone, Francesco Cosimo Pagano, Sara Rocchi, Elisabetta Rota, Andrea Salerno, Matteo Tosato, Marcello Tritto, Riccardo Calvani, Lucio Catalano, Alberto Borghetti, Eleonora Taddei, Leonardo Stella, Paola Cattani Franchi, Simona Marchetti, Alessandra Lauria, Gloria Gambini, Carola Culiersi, Fabrizio Crudo, Mariaconsiglia Santantonio, Danilo Buonsenso, Cristina De Rose, Francesco Lombardi, Marco Modica, Luca Petricca, Anna Laura Fedele, Marco Maria Lizzio, Luca Santoro, Antonio Nesci, Carlo Romano Settanni, Angelo Carfì, Maria Rita Lo Monaco, Anna Maria Martone, Carmen Napolitano, Francesco Pagano, Anna Picca, Giulia Savera, Simona Di Gianbenedetto, Davide Moschese, Arturo Ciccullo, Gertrude Mingrone, Maria Assunta Zocco, Mauirizio Sanguinetti, Alessandro Bizzarro, Maria Cristina Savastano, Maria Grazia Cozzupoli, Giulio Cesare Passali, Giovanni Di Cintio, Ylenia Longobardi, Laura Tricarico, Davide Pata, Davide Sinatti, Cristina. De Rose, Aangelo Calabrese, Delfina Janiri, Giulia Giuseppin, Marzia Molinaro, Anna Rita Larici, Annamaria Paglionico, Laura Gigante, Gerlando Natalello, Anna Laura. Fedele, Marco Maria Lizzio, Valentina Popolla

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Abstract Introduction: The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential for long-term respiratory sequelae in these patients. We assessed the respiratory function in a cohort of patients after recovering from SARS-Cov-2 infection, stratified according to PaO2/FiO2 (p/F) values. Method: Approximately one month after hospital discharge, 86 COVID-19 patients underwent physical examination, arterial blood gas (ABG) analysis, pulmonary function tests (PFTs), and six-minute walk test (6MWT). Patients were also asked to quantify the severity of dyspnoea and cough before, during, and after hospitalization using a visual analogic scale (VAS). Seventy-six subjects with ABG during hospitalization were stratified in three groups according to their worst p/F values: above 300 (n = 38), between 200 and 300 (n = 30) and below 200 (n = 20). Results: On PFTs, lung volumes were overall preserved yet, mean percent predicted residual volume was slightly reduced (74.8 ± 18.1%). Percent predicted diffusing capacity for carbon monoxide (DLCO) was also mildly reduced (77.2 ± 16.5%). Patients reported residual breathlessness at the time of the visit (VAS 19.8, p < 0.001). Patients with p/F below 200 during hospitalization had lower percent predicted forced vital capacity (p = 0.005), lower percent predicted total lung capacity (p = 0.012), lower DLCO (p < 0.001) and shorter 6MWT distance (p = 0.004) than patients with higher p/F. Conclusion: Approximately one month after hospital discharge, patients with COVID-19 can have residual respiratory impairment, including lower exercise tolerance. The extent of this impairment seems to correlate with the severity of respiratory failure during hospitalization.
Lingua originaleEnglish
pagine (da-a)241-248
Numero di pagine8
RivistaBMC Pulmonary Medicine
Volume21
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • 6MWT
  • ABG
  • COVID
  • PFT
  • cough
  • dyspnoea

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