TY - JOUR
T1 - Resection of the internal carotid artery in selected patients affected by cancer of the skull base
AU - Ferrari, Marco
AU - Zanoletti, Elisabetta
AU - Taboni, Stefano
AU - Cazzador, Diego
AU - Tealdo, Giulia
AU - Schreiber, Alberto
AU - Mattavelli, Davide
AU - Rampinelli, Vittorio
AU - Doglietto, Francesco
AU - Fontanella, Marco Maria
AU - Buffoli, Barbara
AU - Vural, Alperen
AU - Verzeletti, Vincenzo
AU - Carobbio, Andrea Luigi Camillo
AU - Mardighian, Dikran
AU - Causin, Francesco
AU - Orlandi, Ester
AU - Cenzato, Marco
AU - Rezzani, Rita
AU - Nicolai, Piero
PY - 2022
Y1 - 2022
N2 - Invasion of the internal carotid artery (ICA) has been historically considered a criterion of non-resectability of skull base cancer (SBC). Patients affected by SBC who underwent surgery including resection of ICA at two tertiary institutions were included. Demographics, oncologic, and surgical information, complications, and survival outcomes were retrospectively reviewed. Survival outcomes were calculated. Ten patients were included. Three surgical approaches (transnasal endoscopic, transorbital, and transpetrosal) were employed to resect the invaded/abutted tract(s) of the ICA. All patients underwent ICA temporary balloon occlusion test. In two patients, an extracranial-to-intracranial arterial bypass was harvested. Major neuromorbidity was observed in two patients. Perioperative mortality of the series was 10.0%. Mean overall survival was 27.2 months, with 2-year overall and progression-free survival rate of 88.9%. ICA resection is feasible as part of the ablation performed for very advanced SBCs. Survival outcomes are acceptable in adequately selected patients.
AB - Invasion of the internal carotid artery (ICA) has been historically considered a criterion of non-resectability of skull base cancer (SBC). Patients affected by SBC who underwent surgery including resection of ICA at two tertiary institutions were included. Demographics, oncologic, and surgical information, complications, and survival outcomes were retrospectively reviewed. Survival outcomes were calculated. Ten patients were included. Three surgical approaches (transnasal endoscopic, transorbital, and transpetrosal) were employed to resect the invaded/abutted tract(s) of the ICA. All patients underwent ICA temporary balloon occlusion test. In two patients, an extracranial-to-intracranial arterial bypass was harvested. Major neuromorbidity was observed in two patients. Perioperative mortality of the series was 10.0%. Mean overall survival was 27.2 months, with 2-year overall and progression-free survival rate of 88.9%. ICA resection is feasible as part of the ablation performed for very advanced SBCs. Survival outcomes are acceptable in adequately selected patients.
KW - cancer
KW - head and neck
KW - internal carotid artery
KW - skull base
KW - vascular surgical procedure
KW - Head and Neck Neoplasms
KW - Humans
KW - Retrospective Studies
KW - Skull Base
KW - Cerebral Revascularization
KW - Carotid Artery, Internal
KW - cancer
KW - head and neck
KW - internal carotid artery
KW - skull base
KW - vascular surgical procedure
KW - Head and Neck Neoplasms
KW - Humans
KW - Retrospective Studies
KW - Skull Base
KW - Cerebral Revascularization
KW - Carotid Artery, Internal
UR - http://hdl.handle.net/10807/230285
U2 - 10.1002/hed.26967
DO - 10.1002/hed.26967
M3 - Article
SN - 1043-3074
VL - 44
SP - 1030
EP - 1042
JO - HEAD & NECK
JF - HEAD & NECK
ER -
